Skip to main content
News Icon

Publication

Immune memory characteristics of innate lymphoid cells

Immune memory characteristics of innate lymphoid cells -A Review

Immunological memory is an evolutionally acquired trait that allows a more robust response of an organism to re-infection. Two types of immune memory have been characterized: adaptive immune memory that is antigen-specific and is generated by adaptive immune cells, and trained immunity that is unspecific and developed by innate immune cells such as macrophages. This clear dichotomy fades when it comes to the immune cell compartment that shares characteristics of both: innate and adaptive immunity such as natural killer cells, innate lymphoid cells or gd T cells. In this review we describe what has been revealed so far about memory characteristics of innate-like immune cells that bridge the two types of immune response. We try to answer a still intriguing question: what kind of immune memory do innate-like cells develop?


Publication

https://www.immunosensation.de/research/publications/pubmed/immune-memory-characteristics-of-innate-lymphoid-cells.html


Contact

Prof. Mihai Netea

LIMES Institute

Related news

PM Immunity Nebeling

Publication

Study reveals dynamic interactions between brain tumors and immune cells

—Glioblastoma, the most common and aggressive brain tumor in adults, is difficult to treat because this cancer can invade the surrounding brain tissue and spread far beyond the original tumor mass. Researchers from the DZNE, the University Hospital Bonn (UKB), and ImmunoSensation³ at the University of Bonn have observed this infiltration process in the living brain using high-tech microscopy. Their study is based on research in mice with a form of brain tumor that closely resembles human glioblastoma.
View entry
Nora Möhn

Publication

New Findings on Immunotherapy for a Rare Brain Infection

—Progressive multifocal leukoencephalopathy (PML) is a rare but very serious brain disease. It is caused by the reactivation of the widespread JC virus when the immune system is severely weakened. There is currently no targeted antiviral therapy available, which is why new treatment approaches are urgently needed. In recent years, so-called immune checkpoint inhibitors have been increasingly used; these “unlock” the immune system and reactivate the body’s own immune cells. The results were recently published in the journal JAMA Neurology.
View entry
Die künstlerische Abbildung zeigt Seeigel der Art Arbacia punctulata, die Spermien (weiße Wolke) und Eier (orangefarbene Wolke) ins Wasser abgeben. Von den Eiern freigesetzte Pheromone steuern die Synchronität des Laichens.

Publication

What Makes Sea Urchin and Salmon Sperm Swim

—A recent study by the Max Planck Institute for Multidisciplinary Sciences and the University of Bonn shows that pH plays a crucial role in sperm motility in sea urchins and salmon. A rise in pH activates the enzyme soluble adenylyl cyclase (sAC), which produces the messenger molecule cAMP and thereby regulates sperm movement. This mechanism may be widespread in many marine invertebrates and fish. The findings have now been published in the Journal Proceedings of the National Academy of Sciences.
View entry

Back to the news overview