Skip to main content
News Icon

Publication

Immune memory characteristics of innate lymphoid cells

Immune memory characteristics of innate lymphoid cells -A Review

Immunological memory is an evolutionally acquired trait that allows a more robust response of an organism to re-infection. Two types of immune memory have been characterized: adaptive immune memory that is antigen-specific and is generated by adaptive immune cells, and trained immunity that is unspecific and developed by innate immune cells such as macrophages. This clear dichotomy fades when it comes to the immune cell compartment that shares characteristics of both: innate and adaptive immunity such as natural killer cells, innate lymphoid cells or gd T cells. In this review we describe what has been revealed so far about memory characteristics of innate-like immune cells that bridge the two types of immune response. We try to answer a still intriguing question: what kind of immune memory do innate-like cells develop?


Publication

https://www.immunosensation.de/research/publications/pubmed/immune-memory-characteristics-of-innate-lymphoid-cells.html


Contact

Prof. Mihai Netea

LIMES Institute

Related news

News_Lukacs-Kornek

Publication

Obesity causes lungs to age prematurely

—What effects does severe obesity have on the lungs? A research team led by Prof. Dr. Veronika Lukacs-Kornek from the ‘ImmunoSensation2’ Cluster of Excellence at the University of Bonn and the Institute for Molecular Medicine and Experimental Immunology (IMMEI) at the University Hospital Bonn (UKB) investigated this question. The results suggest that obesity causes the lungs to age faster. The findings have been published in the journal ‘Cell Reports’.
View entry
filamentous actin structures in T cells

Publication

How Cell Skeleton Defects Can Teach Immunology

—For immune cells, the actin cytoskeleton is more than a structural scaffold. Immune cells can migrate to sites of infection or form precise, short-lived contacts with other cells, by constantly reshaping their actin cytoskeleton. Genetic errors in the molecular machinery controlling actin dynamics lead to impaired immunity, and often to autoimmunity and chronic inflammation. An overview of the current state of research on immune-related actinopathies, prepared by scientists arround ImmunoSensation² member Prof. Kaan Boztug, has now been published in Nature Reviews Immunology.
View entry
Wachten lab

Publication

Fat cells under false command

—Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue. That is why a team led by researchers from the University Hospital Bonn (UKB) and the University of Bonn investigated the influence of primary cilia dysfunction on adipocyte precursor cells in a mouse model. They found that overactivation of the Hedgehog signaling pathway causes abnormal development into connective tissue-like cells instead of white fat cells. Their findings have now been published in The EMBO Journal.
View entry

Back to the news overview