Skip to main content
News Latz 12.2019
Investigated the fine-tuning of macrophages: Prof. Dr. Eicke Latz (left) and Mario Lauterbach (right) from the Institute of Innate Immunity at the University of Bonn.
© Rolf Müller/UKB

Publication

Macrophage Metabolism Publication in Immunity

Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead. Upon coming into contact with bacteria they change their metabolism drastically within minutes. This is shown by a new study under the leadership of the University of Bonn, which has now been published in the journal "Immunity". In the medium term, the results may lead to new vaccination strategies, but also to new approaches for combating autoimmune diseases.

The Study was lead by Cluster Member and Speaker Prof. Eicke Latz.


Publication

Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S. J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller & Eicke Latz: Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase; Immunity; DOI: 10.1016/j.immuni.2019.11.009

Related news

Smartphone-based retinal imaging in clinical practice in India: - The image was taken during a collaborative project between University Hospital Bonn (UKB) and Sankara Eye Foundation India on smartphone-based telemedical screening for diabetic retinopathy.

Publication

Smartphones as Retinal Cameras: New Opportunities for Global Eye Care

—Smartphones could play an important role in the early detection of eye diseases, including in settings where specialized ophthalmic infrastructure is limited. An international team of experts led by the UKB and the University of Bonn has comprehensively reviewed the current global landscape of smartphone-based fundus imaging. The researchers highlight the technical and clinical possibilities that already exist today, identify the limitations of these methods, and outline the conditions that must be met so that smartphone-based retinal imaging can be more widely integrated into screening.
View entry
Pseudocolored electron microscope image of a macrophage

Publication

Microplastics Cause Fatty Liver Disease in Mice

—Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These are the key findings from a joint German-Austrian study led by the University of Bonn, details of which have now been published in the journal “Nature Metabolism.”
View entry
Pressefoto

Publication

Decoding the Effects of Obesity

—A group of innate immune cells known as group 2 innate lymphoid cells (ILC2s) are essential for maintaining a healthy metabolic balance in adipose tissue. Obesity significantly impairs the number and function of ILC2s. How ILC2s are disrupted by obesity has so far remained unclear. Researchers from the UKB and the University of Bonn have now shown in obese mice that acetyl-CoA carboxylase 1, a key enzyme in fatty acid biosynthesis, is a crucial regulator of the maintenance and function of ILC2 immune cells in adipose tissue. The results have now been published in the journal Cell Metabolism.
View entry

Back to the news overview