Skip to main content
News Latz 12.2019
Investigated the fine-tuning of macrophages: Prof. Dr. Eicke Latz (left) and Mario Lauterbach (right) from the Institute of Innate Immunity at the University of Bonn.
© Rolf Müller/UKB

Publication

Macrophage Metabolism Publication in Immunity

Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead. Upon coming into contact with bacteria they change their metabolism drastically within minutes. This is shown by a new study under the leadership of the University of Bonn, which has now been published in the journal "Immunity". In the medium term, the results may lead to new vaccination strategies, but also to new approaches for combating autoimmune diseases.

The Study was lead by Cluster Member and Speaker Prof. Eicke Latz.


Publication

Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S. J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller & Eicke Latz: Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase; Immunity; DOI: 10.1016/j.immuni.2019.11.009

Related news

News_Lukacs-Kornek

Publication

Obesity causes lungs to age prematurely

—What effects does severe obesity have on the lungs? A research team led by Prof. Dr. Veronika Lukacs-Kornek from the ‘ImmunoSensation2’ Cluster of Excellence at the University of Bonn and the Institute for Molecular Medicine and Experimental Immunology (IMMEI) at the University Hospital Bonn (UKB) investigated this question. The results suggest that obesity causes the lungs to age faster. The findings have been published in the journal ‘Cell Reports’.
View entry
filamentous actin structures in T cells

Publication

How Cell Skeleton Defects Can Teach Immunology

—For immune cells, the actin cytoskeleton is more than a structural scaffold. Immune cells can migrate to sites of infection or form precise, short-lived contacts with other cells, by constantly reshaping their actin cytoskeleton. Genetic errors in the molecular machinery controlling actin dynamics lead to impaired immunity, and often to autoimmunity and chronic inflammation. An overview of the current state of research on immune-related actinopathies, prepared by scientists arround ImmunoSensation² member Prof. Kaan Boztug, has now been published in Nature Reviews Immunology.
View entry
Wachten lab

Publication

Fat cells under false command

—Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue. That is why a team led by researchers from the University Hospital Bonn (UKB) and the University of Bonn investigated the influence of primary cilia dysfunction on adipocyte precursor cells in a mouse model. They found that overactivation of the Hedgehog signaling pathway causes abnormal development into connective tissue-like cells instead of white fat cells. Their findings have now been published in The EMBO Journal.
View entry

Back to the news overview