Skip to main content
News Latz 12.2019
Investigated the fine-tuning of macrophages: Prof. Dr. Eicke Latz (left) and Mario Lauterbach (right) from the Institute of Innate Immunity at the University of Bonn.
© Rolf Müller/UKB

Publication

Macrophage Metabolism Publication in Immunity

Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead. Upon coming into contact with bacteria they change their metabolism drastically within minutes. This is shown by a new study under the leadership of the University of Bonn, which has now been published in the journal "Immunity". In the medium term, the results may lead to new vaccination strategies, but also to new approaches for combating autoimmune diseases.

The Study was lead by Cluster Member and Speaker Prof. Eicke Latz.


Publication

Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S. J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller & Eicke Latz: Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase; Immunity; DOI: 10.1016/j.immuni.2019.11.009

Related news

PM Immunity Nebeling

Publication

Study reveals dynamic interactions between brain tumors and immune cells

—Glioblastoma, the most common and aggressive brain tumor in adults, is difficult to treat because this cancer can invade the surrounding brain tissue and spread far beyond the original tumor mass. Researchers from the DZNE, the University Hospital Bonn (UKB), and ImmunoSensation³ at the University of Bonn have observed this infiltration process in the living brain using high-tech microscopy. Their study is based on research in mice with a form of brain tumor that closely resembles human glioblastoma.
View entry
Nora Möhn

Publication

New Findings on Immunotherapy for a Rare Brain Infection

—Progressive multifocal leukoencephalopathy (PML) is a rare but very serious brain disease. It is caused by the reactivation of the widespread JC virus when the immune system is severely weakened. There is currently no targeted antiviral therapy available, which is why new treatment approaches are urgently needed. In recent years, so-called immune checkpoint inhibitors have been increasingly used; these “unlock” the immune system and reactivate the body’s own immune cells. The results were recently published in the journal JAMA Neurology.
View entry
Die künstlerische Abbildung zeigt Seeigel der Art Arbacia punctulata, die Spermien (weiße Wolke) und Eier (orangefarbene Wolke) ins Wasser abgeben. Von den Eiern freigesetzte Pheromone steuern die Synchronität des Laichens.

Publication

What Makes Sea Urchin and Salmon Sperm Swim

—A recent study by the Max Planck Institute for Multidisciplinary Sciences and the University of Bonn shows that pH plays a crucial role in sperm motility in sea urchins and salmon. A rise in pH activates the enzyme soluble adenylyl cyclase (sAC), which produces the messenger molecule cAMP and thereby regulates sperm movement. This mechanism may be widespread in many marine invertebrates and fish. The findings have now been published in the Journal Proceedings of the National Academy of Sciences.
View entry

Back to the news overview