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Possible SARS-CoV-2 mass testing with new technology

Prof. Dr. Jonathan Schmid-Burgk heads the new working group for "Functional Immunogenomics" at the Institute for Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn. As part of the newly established professorship and management position, the 34-year-old genome researcher is investigating the complex interplay between genes and our immune system. With the help of robotics and artificial intelligence (AI), he is developing new techniques for protein analysis in living human cells with programmable gene scissors. The aim is to accelerate the modification of the human genome in order to analyze it. Prof. Schmid-Burgk is currently working on a mass test for COVID-19 using the LAMP-Seq process he developed. He brings his new techniques to the Cluster of Excellence ImmunoSensation at the University of Bonn. Following his doctorate, for which he received the doctoral award from the Bonn University Society in 2017, his previous academic career led Prof. Schmid-Burgk to Cambridge (USA). There he spent three and a half years researching at the Broad Institute of MIT and Harvard - funded by a grant from the European Molecular Biology Organization (EMBO).

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Malaria Causes Permanent Damage to Phagocytes in the Spleen

Macrophages formed in the bone marrow can only assume the function of embryonal phagocytes, or “scavenger cells,” to a certain degree according to a study by the University of Bonn and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne. The researchers have demonstrated that malaria infection causes permanent damage to resident CD163 macrophages in the spleen, which are responsible for cleaning the blood, recycling iron and communicating with other cells involved in the body’s immune response.
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Tracking glioblastoma cell spread in human brain tissue

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Core2Edge: How tumor cells conquer the brain

Glioblastoma is an aggressive brain tumor that infiltrates deep into the surrounding brain tissue. Even after surgery, tumor cells remain in the brain and the tumor recurs. Bonn researchers have now developed Core2Edge, a model based entirely on human tissue that captures these hard-to-access infiltration zones at the tumor margin. The model enables investigation of the invasive front and direct assessment of new drug candidates in human tissue - without the need for animal testing. The study of the Brain Tumor Translational Research Group has now been published in Nature Protocols.
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Mikrochip zur Wiederherstellung zentralen Sehvermögens bei fortgeschrittener Makuladegeneration.

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Approval of a Novel Retinal Implant Technology

A novel retinal implant is offering people with geographic atrophy the opportunity to regain part of their central vision for the first time. Geographic atrophy is a severe late stage of age-related macular degeneration. An international research team led by Prof. Frank G. Holz of the UKB and the University of Bonn demonstrated in an international clinical trial that the majority of participants experienced significant improvements in visual acuity. The novel retinal implant technology has now received approval for routine clinical use in Europe, making it available beyond clinical trials.
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