Skip to main content
News Mass 02.2020
Microscopic image of green stained macrophages after a stroke: The additional red stained cell (top right) originates from the bone marrow, the pure green cells are resident microglia.
© AG Stumm

Publication

Publication by Mass Group in Nature Neuroscience

Stroke: Macrophages migrate from the blood

Molecular switch in bone marrow stem cells helps research into inflammatory processes in the brain.

Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the Cluster of Excellence ImmunoSensation and the Memorial Sloan Kettering Cancer Center in New York (USA) succeeded in visualizing macrophages that were formed in the bone marrow. In studies on mice, this technology enabled the researchers to observe that shortly after a stroke, numerous macrophages that had migrated from the blood begin to attack dead and adjacent healthy brain tissue. The results have now been published in the journal "Nature Neuroscience". Prof. Elvira Mass - leading author of this publication - is a member of the Cluster of Excellence ImmunoSensation2.


Publication

Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L. Schultze, Frederic Geissmann & Ralf Stumm: Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke, Nature Neuroscience, DOI: 10.1038/s41593-020-0585-y


Media contact

Prof. Dr. Elvira Mass

Life & Medical Sciences Institute (LIMES)

Universität Bonn

Tel. +49-(0)228-7362848

E-mail: elvira.mass@uni-bonn.de

Related news

Neurons - generated through the differentiation of induced neural stem cells (iNSCs) derived from blood.

Publication

Researchers Transform Old Blood Cells into Young Brain Cells

—Researchers from the University Hospital of Bonn and the University of Bonn have succeeded in dramatically rejuvenating human cells in a test tube. To do so, they directly reprogrammed red blood cell precursors into stem cells from which neurons can be derived. During this process, the molecular clocks that indicate a cell’s age were reset. For example, blood cells from an 80-year-old were transformed into stem cells with a molecular age of less than 20 years. The results have been published in the journal Aging Cell.
View entry
Dr. Robert Hüneburg, Dr. Anne-Sophie Layritz, and Nicola Reents (from left) - conducted a survey and found that fewer than one in ten people with Lynch syndrome take Acetylsalicylic acid for cancer prevention – despite a high level of openness to new preventive approaches.

Publication

Aspirin Rarely Used for Colorectal Cancer Prevention

—According to international studies, taking Acetylsalicylic acid daily can protect people with Lynch syndrome from developing colorectal cancer – even at low doses. Researchers from the University Hospital Bonn (UKB), the University of Bonn, and the Center for Integrated Oncology (CIO) Bonn, in collaboration with the self-help organization SemiColon, have now found that these scientific findings have so far been insufficiently incorporated into clinical practice. The results of the LYNX study have now been published as a letter in the journal The Lancet Gastroenterology & Hepatology.
View entry
Smartphone-based retinal imaging in clinical practice in India: - The image was taken during a collaborative project between University Hospital Bonn (UKB) and Sankara Eye Foundation India on smartphone-based telemedical screening for diabetic retinopathy.

Publication

Smartphones as Retinal Cameras: New Opportunities for Global Eye Care

—Smartphones could play an important role in the early detection of eye diseases, including in settings where specialized ophthalmic infrastructure is limited. An international team of experts led by the UKB and the University of Bonn has comprehensively reviewed the current global landscape of smartphone-based fundus imaging. The researchers highlight the technical and clinical possibilities that already exist today, identify the limitations of these methods, and outline the conditions that must be met so that smartphone-based retinal imaging can be more widely integrated into screening.
View entry

Back to the news overview