Skip to main content
News Icon

News categories: Publication

Regulation of Innate Immune Responses by Platelets

Platelets have been extensively studied in the context of coagulation and their hemostatic imbalance can lead to conditions as atherosclerotic plaques and thrombosis. Nevertheless, the knowledge regarding the regulation of immune cell types by platelets has been growing exponentially in the past years. Among these biological systems, the innate immunity is remarkably affected by the crosstalk with platelets. This interaction comes from the formation of platelet-leukocyte aggregates, signaling by direct contact or by stimulation of immune cells by soluble factors and microparticles secreted by platelets. These blood components can sense and react danger signals, guiding leukocytes to injury sites and providing a scaffold for the formation of extracellular traps for microbial clearance. Using different mechanisms, platelets have the task to regulate the release of cytokines and chemokines upon sterile or infectious damage, modulate the expression of cell markers and control cell death and survival. Therefore, platelets are more than clotting agents, but critical players within the immune equilibrium for the host. Here we present an understanding about how platelets modulate innate immune cells, as well as a summary of the outcome of this interaction, an important step for therapeutic opportunities and future research on infectious and autoimmune diseases.


Publication

https://www.immunosensation.de/research/publications/pubmed/regulation-of-innate-immune-responses-by-platelets.html


Contact

Prof. Bernardo Franklin

Institute of Innate Immunity

Related news

18062025_Mass_Nature_Figure Hepatozyten

News categories: Publication

How obesity also affects the next generation

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves. A new study from the group of Elvira Mass at the University of Bonn offers an explanation for this phenomenon. In obese mice, certain cells in the embryo’s liver are reprogrammed during pregnancy. This leads to long-term changes in the offspring’s metabolism. The researchers believe that these findings could also be relevant for humans. The study has now been published in the journal Nature.
View entry
Microglia interacting with T cells in the central nervous system of SPG15-deficient mice

News categories: Publication

Immune Cells Drive Congenital Paralysis Disease

Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease the brain appears to play a major role by over-activating the immune system, as shown by a recent study published in the Journal of Experimental Medicine. The study was led by researchers at the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE). These findings could also be relevant for Alzheimer's disease and other neurodegenerative conditions.
View entry
Scientists that contributed to the study

News categories: Publication

New way to prevent duodenal cancer

People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP. The results have now been published in the journal "Nature Communications".
View entry

Back to the news overview