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Accumulating Evidence Supports NECTIN4 as a Predictive Biomarker for Enfortumab Vedotin: The Compartment Still Matters.

European urology

Authors: Niklas Klümper, Jonathan E Rosenberg, David H Aggen, Markus Eckstein

Accumulating data support nectin-4, particularly membranous expression, as a predictive biomarker of enfortumab vedotin activity. Low expression identifies patients with poorer outcomes but not absence of benefit, underscoring the need for standardized prospective validation before clinical implementation.

Copyright © 2026 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PMID: 42829269

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