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  • Uridine diphosphate-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase deletion in mice leads to lethal intracerebral hemorrhage during embryonic development.

    Glycobiology

    Authors: Henri Wedekind, Elina Kats, Anna-Carina Weiss, Hauke Thiesler, Christine Klaus, Andreas Kispert, Rüdiger Horstkorte, Harald Neumann, Birgit Weinhold, Anja Münster-Kühnel, Markus Abeln

  • Targeting sialylation to treat central nervous system diseases.

    Trends in pharmacological sciences

    Authors: Jan D Lünemann, Stephan von Gunten, Harald Neumann

  • Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice.

    Glia

    Authors: Huan Liao, Jonas Winkler, Jannis Wißfeld, Anahita Shahraz, Christine Klaus, Harald Neumann

  • Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia.

    Scientific reports

    Authors: Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle, Harald Neumann

  • Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype.

    Glia

    Authors: Jannis Wißfeld, Ichiro Nozaki, Mona Mathews, Tamara Raschka, Christian Ebeling, Veit Hornung, Oliver Brüstle, Harald Neumann

  • Sialylation acts as a checkpoint for innate immune responses in the central nervous system.

    Glia

    Authors: Christine Klaus, Huan Liao, David H Allendorf, Guy C Brown, Harald Neumann

  • A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region.

    Glia

    Authors: Melanie Ibach, Mona Mathews, Bettina Linnartz-Gerlach, Sandra Theil, Sathish Kumar, Regina Feederle, Oliver Brüstle, Harald Neumann, Jochen Walter

  • Control of Innate Immunity by Sialic Acids in the Nervous Tissue.

    International journal of molecular sciences

    Authors: Huan Liao, Christine Klaus, Harald Neumann

  • Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides.

    Glia

    Authors: Anahita Shahraz, Jannis Wißfeld, Aurélien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neumann

  • Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.

    Neurobiology of aging

    Authors: Christine Klaus, Jan N Hansen, Aurélien Ginolhac, Deborah Gérard, Vinayaga S Gnanapragassam, Rüdiger Horstkorte, Charlotte Rossdam, Falk F R Buettner, Thomas Sauter, Lasse Sinkkonen, Harald Neumann, Bettina Linnartz-Gerlach