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  • Evaluating Sorafenib (SORA-2) as Second-Line Treatment for Unresectable Hepatocellular Carcinoma: A European Retrospective Multicenter Study.

    Cancers

    Authors: Christian Möhring, Moritz Berger, Farsaneh Sadeghlar, Xin Zhou, Taotao Zhou, Malte Benedikt Monin, Kateryna Shmanko, Sabrina Welland, Friedrich Sinner, Birgit Schwacha-Eipper, Ulrike Bauer, Christoph Roderburg, Angelo Pirozzi, Najib Ben Khaled, Peter Schrammen, Lorenz Balcar, Matthias Pinter, Thomas J Ettrich, Anna Saborowski, Marie-Luise Berres, Enrico N De Toni, Tom Lüdde, Lorenza Rimassa, Ursula Ehmer, Marino Venerito, Iuliana-Pompilia Radu, Ingo G H Schmidt-Wolf, Arndt Weinmann, Arndt Vogel, Matthias Schmid, Jörg C Kalff, Christian P Strassburg, Maria A Gonzalez-Carmona

  • Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6.

    RSC medicinal chemistry

    Authors: Silas L Wurnig, Maria Hanl, Thomas M Geiger, Shiyang Zhai, Ina Dressel, Dominika E Pieńkowska, Radosław P Nowak, Finn K Hansen

  • Immune training enhances anti-viral responses and improves outcomes in Pax5 mice susceptible to chronic infection.

    EMBO molecular medicine

    Authors: Zhe Lu, Olivia Stencel, Wei Liu, Eleni Vasileiou, Haifeng C Xu, Piyush Pandey, Paweł Stachura, Abdelrahman Elwy, Anastassia Tsombal, Ann-Sophie Mai, Franziska Auer, Mina N F Morcos, Maximilian Seidl, Sarah Koziel, Peter-Martin Bruch, Sascha Dietrich, Sarah Elitzur, Gunther Hartmann, Karl S Lang, Stefan Janssen, Ute Fischer, Sanil Bhatia, Philipp A Lang, Arndt Borkhardt, Julia Hauer, Aleksandra A Pandyra

  • A versatile toolbox for determining IRES activity in cells and embryonic tissues.

    The EMBO journal

    Authors: Philipp Koch, Zijian Zhang, Naomi R Genuth, Teodorus Theo Susanto, Martin Haimann, Alena Khmelinskaia, Gun Woo Byeon, Saurabh Dey, Maria Barna, Kathrin Leppek

  • The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.

    Cellular and molecular life sciences : CMLS

    Authors: Onur Kerem Tever, Torben Mentrup, Ivan Kingyue Chinn, Hitoshi Ishikuma, Regina Fluhrer, Marc Schmitz, Rebekka Wehner, Rayk Behrendt, Javier Chinen, Bernd Schröder

  • DataSHIELD: mitigating disclosure risk in a multi-site federated analysis platform.

    Bioinformatics advances

    Authors: Demetris Avraam, Rebecca C Wilson, Noemi Aguirre Chan, Soumya Banerjee, Tom R P Bishop, Olly Butters, Tim Cadman, Luise Cederkvist, Liesbeth Duijts, Xavier Escribà Montagut, Hugh Garner, Gonçalo Gonçalves, Juan R González, Sido Haakma, Mette Hartlev, Jan Hasenauer, Manuel Huth, Eleanor Hyde, Vincent W V Jaddoe, Yannick Marcon, Michaela Th Mayrhofer, Fruzsina Molnar-Gabor, Andrei Scott Morgan, Madeleine Murtagh, Marc Nestor, Anne-Marie Nybo Andersen, Simon Parker, Angela Pinot de Moira, Florian Schwarz, Katrine Strandberg-Larsen, Morris A Swertz, Marieke Welten, Stuart Wheater, Paul Burton

  • A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8 T cell fitness in solid tumours.

    Nature metabolism

    Authors: Samantha Pretto, Qian Yu, Pierre Bourdely, Sarah Trusso Cafarello, Heleen H Van Acker, Joren Verelst, Elena Richiardone, Lotte Vanheer, Amir Roshanzadeh, Franziska Schneppenheim, Charlotte Cresens, Maria Livia Sassano, Jonas Dehairs, Martin Carion, Shehab Ismail, Patrizia Agostinis, Susana Rocha, Tobias Bald, Johan Swinnen, Cyril Corbet, Sophia Y Lunt, Bernard Thienpont, Mario Di Matteo, Massimiliano Mazzone

  • Unveiling IRF4-steered regulation of context-dependent effector programs in CD4 T cells under Th17- and Treg-skewing conditions.

    Cell reports

    Authors: Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

  • Phosphatidylcholine synthesis and remodeling in brain endothelial cells.

    Journal of lipid research

    Authors: Mohamed H Yaghmour, Theja Sajeevan, Christoph Thiele, Lars Kuerschner

  • Ablation of symptomatic uterine fibroids with the Mirabilis system for rapid noninvasive ultrasound-guided high-intensity focused ultrasound (HIFU): a prospective observational clinical study.

    La Radiologia medica

    Authors: Tolga Tonguc, Oleksandr Savchenko, Olga Ramig, Judith M Stader, Franziska Kießling, Jim Küppers, Eva K Egger, Marcus Thudium, Patrick Martin, Wayne Poll, Hans H Schild, Rupert Conrad, Markus Essler, Alexander Mustea, Holger M Strunk, Milka Marinova