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  • Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K Degraders.

    Journal of medicinal chemistry

    Authors: Thiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Anna Iermolaieva, Pompom Ghosh, John Mosior, Luxin Sun, Dylan Grassie, Maximilian Schmitz, Mahalakshmi Naidu Kalaga, William Albritton, Manuel Manzanares Rodas, Sean Chin Chan, Sylvia Frydman, Samer Sansil, Matthias Geyer, Ernst Schönbrunn, William R Roush, Derek R Duckett, Andrii Monastyrskyi

  • A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.

    Nature immunology

    Authors: Saumya Kumar, Chaofan Li, Liang Zhou, Qiuyao Zhan, Ahmed Alaswad, Sonja Volland, Bibiana Costa, Simon Alexander Krooss, Isabel Klefenz, Hagen Schmaus, Antonia Zeuzem, Dorothee von Witzendorff, Helena Lickei, Lea Pueschel, Anke R M Kraft, Markus Cornberg, Andreas Rembert Koczulla, Isabell Pink, Marius M Hoeper, Cheng-Jian Xu, Susanne Häussler, Miriam Wiestler, Mihai G Netea, Thomas Illig, Jie Sun, Yang Li

  • Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.

    Nature communications

    Authors: Linda Klümpen, Aakash Mantri, Maren Philipps, Waldemar Seel, Laura Schlautmann, Mohamed H Yaghmour, Verena Wiemann, Birgit Stoffel-Wagner, Martin Coenen, Leonie Weinhold, Jan Hasenauer, Thomas Fließwasser, Sven Burgdorf, Christoph Thiele, Peter Stehle, Marie-Christine Simon

  • A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation.

    Nature communications

    Authors: Isabel Stötzel, Ann-Kathrin Weier, Apurba Sarkar, Subhendu Som, Luisa Bach, Peter Konopka, Eliška Miková, Shaunak Ghosh, Jan Böthling, Mirka Homrich, Laura Schaedel, Uli Kazmaier, Konstantinos Symeonidis, Stefan Ebner, Philip Weidner, Zeinab Abdullah, Felix Meissner, Stefan Uderhardt, Miroslav Hons, Dirk Baumjohann, Raja Paul, Heiko Rieger, Eva Kiermaier

  • Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids.

    Cell stem cell

    Authors: Kritika Sharma, Rouhollah Habibey, Mariana M Ribeiro, Bohao Cui, Rebecca A Siwicki, Johannes Striebel, Julia S Pawlick, Jasmin Zorn, Larissa Utz, Magdalena Renner, Simone Picelli, Frank G Holz, Carmen Ruiz de Almodóvar, Cameron S Cowan, Volker Busskamp

  • Delay From First Symptoms in Patients Presenting With STEMI and Cardiogenic Shock: Insights From the DanGer Shock Trial.

    Circulation. Cardiovascular interventions

    Authors: Lisette Okkels Jensen, Rasmus Paulin Beske, Hans Eiskjær, Norman Mangner, Amin Polzin, P Christian Schulze, Carsten Skurk, Peter Nordbeck, Peter Clemmensen, Vasileios Panoulas, Sebastian Zimmer, Andreas Schäfer, Nikos Werner, Lene Holmvang, Kristian Wachtell, Thomas Engstøm, Nanna Louise Junker Udesen, Henrik Schmidt, Anders Junker, Christian Juhl Terkelsen, Steffen Christensen, Axel Linke, Jacob Eifer Møller, Christian Hassager

  • Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis.

    Cell death & disease

    Authors: Jincheng Gao, Almke Bader, Monika I Linder, Jingyuan Cheng, Mathis Richter, Raul da Costa, Annette Zehrer, Karl Mitt, Bastian Popper, Felix Meissner, Xiang Wei, Enrique de Vega Gómez, Megumi Tatematsu, Meino Rohlfs, Stephanie Frenz-Wiessner, Mehmet Kiziltug, Ido Somekh, Joanne Yacobovich, Orna Steinberg-Shemer, Raz Somech, Oliver Soehnlein, Bettina Schmid, Christoph Klein, Barbara Walzog, Daniela Maier-Begandt

  • Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies.

    American journal of human genetics

    Authors: Nataliya Di Donato, Andrew Thom, Andreas Rump, Johannes N Greve, Juan Cadiñanos, Salvatore Calabro, Sara Cathey, Brian Chung, Heidi Cope, Maria Costales, Sara Cuvertino, Philine Dinkel, Kalliopi Erripi, Andrew E Fry, Livia Garavelli, Sabine Hoffjan, Wibke G Janzarik, Insa Kreimer, Grazia Mancini, Purificacion Marin-Reina, Andrea Meinhardt, Indra Niehaus, Daniela Pilz, Ivana Ricca, Fernando Santos Simarro, Evelin Schrock, Anja Marquardt, Manuel H Taft, Kamer Tezcan, Sofia Thunström, Judith Verhagen, Alain Verloes, Bernd Wollnik, Peter Krawitz, Tzung-Chien Hsieh, Michael Seifert, Michael Heide, Catherine B Lawrence, Neil A Roberts, Dietmar J Manstein, Adrian S Woolf, Siddharth Banka

  • Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX).

    Leukemia

    Authors: Andreas Burchert, Franck E Nicolini, Philipp le Coutre, Susanne Saussele, Andreas Hochhaus, Evin Tuere, Stephan K Metzelder, Kim Pauck, Holger Garn, Hartmann Raifer, Magdalena Huber, Norbert Gattermann, Martina Crysandt, Philippe Schafhausen, Matthias Bormann, Markus P Radsak, Agnès Guerci-Bresler, Thomas Illmer, Maria E Goebeler, Peter Herhaus, Lino L Teichmann, Georg-Nikolaus Franke, Fabian Lang, Stefan W Krause, Robert Möhle, Martine Klausmann, Frank Stegelmann, Christoph Lutz, Gabriel Etienne, Andrea Stoltefuß, Joachim R Göthert, Thomas Ernst, Maisun Abu-Samra, Heinz-Gert Höffkes, Andreas Neubauer, Ying Wang, Paul Weiland, Clara Otto, Lea Kiessler, Theresa Weber, Lea Kroning, Andrea Nist, Thorsten Stiewe, Rüdiger Hehlmann, Behnaz Aminossadati, Michael Wittenberg, Kerstin Winterstein, Thomas Oellerich, Marcus Lechner, Markus Pfirrmann, Carmen Schade-Brittinger, Paul Klemm, Christian Michel

  • Pulmonary vein isolation with a pulsed field system leads to lower levels of miR-23a-3p in the left atrial blood compared to a cryoballoon.

    Scientific reports

    Authors: Andreas Zietzer, Vincent Knappe, Frederick Braun, Philip Düsing, Sophia Grunewald, Ansgar Ackerschott, Laurine Reese, Marko Bulic, Maximilian Funken, Christopher Gestrich, Georg Nickenig, Thomas Beiert