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    The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.

    Cell

    Authors: Rainer Knoll, Elisa T Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K Polansky, Birgit Sawitzki, Leif E Sander, Joachim L Schultze, Anna C Aschenbrenner, Florian Kurth

  • Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial.

    The Lancet. Oncology

    Authors: Selim Corbacioglu, Holger Lode, Susanne Ellinger, Florian Zeman, Meinolf Suttorp, Gabriele Escherich, Konrad Bochennek, Bernd Gruhn, Peter Lang, Marius Rohde, Klaus Michael Debatin, Daniel Steinbach, Andreas Beilken, Ruth Ladenstein, Rainer Spachtholz, Peter Heiss, Dirk Hellwig, Anja Tröger, Michael Koller, Karin Menhart, Markus J Riemenschneider, Saida Zoubaa, Silke Kietz, Marcus Jakob, Gunhild Sommer, Tilman Heise, Patrick Hundsdörfer, Ingrid Kühnle, Dagmar Dilloo, Stefan Schönberger, Georg Schwabe, Irene von Luettichau, Norbert Graf, Paul-Gerhardt Schlegel, Michael Frühwald, Norbert Jorch, Michael Paulussen, Dominik T Schneider, Markus Metzler, Alfred Leipold, Michaela Nathrath, Thomas Imschweiler, Holger Christiansen, Irene Schmid, Roman Crazzolara, Naghmeh Niktoreh, Gunnar Cario, Joerg Faber, Martin Demmert, Florian Babor, Birgit Fröhlich, Stefan Bielack, Toralf Bernig, Johann Greil, Angelika Eggert, Thorsten Simon, Juergen Foell

  • Beneficial Effects of Synbiotics on the Gut Microbiome in Individuals with Low Fiber Intake: Secondary Analysis of a Double-Blind, Randomized Controlled Trial.

    Nutrients

    Authors: Aakash Mantri, Linda Klümpen, Waldemar Seel, Peter Krawitz, Peter Stehle, Bernd Weber, Leonie Koban, Hilke Plassmann, Marie-Christine Simon

  • Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

    HGG advances

    Authors: Jannik Boos, Caspar I van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca V C Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustín Albillos, Jesus M Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Joachim L Schultze, Olaf Riess, Andre Franke, Konrad Rawlik, David Ellinghaus, Alexander Hoischen, Axel Schmidt, Kerstin U Ludwig

  • Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease.

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    Authors: Jonathan Vogelgsang, Niels Hansen, Melina Stark, Michael Wagner, Hans Klafki, Barbara Marcos Morgado, Anke Jahn-Brodmann, Björn Schott, Hermann Esselmann, Chris Bauer, Johannes Schuchhardt, Luca Kleineidam, Steffen Wolfsgruber, Oliver Peters, Luisa-Sophie Schneider, Xiao Wang, Felix Menne, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fliessbach, Ina Vogt, Claudia Bartels, Frank Jessen, Ayda Rostamzadeh, Emrah Duezel, Wenzel Glanz, Enise Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris Rauchmann, Selim Guersel, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy-Kluth, Michael Heneka, Frederic Brosseron, Alfredo Ramierez, Matthias Schmid, Jens Wiltfang

  • Approximating facial expression effects on diagnostic accuracy via generative AI in medical genetics.

    Bioinformatics (Oxford, England)

    Authors: Tanviben Patel, Amna A Othman, Ömer Sümer, Fabio Hellman, Peter Krawitz, Elisabeth André, Molly E Ripper, Chris Fortney, Susan Persky, Ping Hu, Cedrik Tekendo-Ngongang, Suzanna Ledgister Hanchard, Kendall A Flaharty, Rebekah L Waikel, Dat Duong, Benjamin D Solomon

  • Efficient parameter estimation for ODE models of cellular processes using semi-quantitative data.

    Bioinformatics (Oxford, England)

    Authors: Domagoj Dorešić, Stephan Grein, Jan Hasenauer

  • T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

    Nature neuroscience

    Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons

  • High Prevalence of F2 20210G > A in Splanchnic Vein Thrombosis and Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study of Patients with Thrombosis in Atypical Sites.

    Hamostaseologie

    Authors: Dalia Khaddam, Hannah L McRae, Nadine Schwarz, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl, Sara Reda

  • Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices.

    Nature communications

    Authors: Péter Berki, Csaba Cserép, Zsuzsanna Környei, Balázs Pósfai, Eszter Szabadits, Andor Domonkos, Anna Kellermayer, Miklós Nyerges, Xiaofei Wei, Istvan Mody, Araki Kunihiko, Heinz Beck, He Kaikai, Wang Ya, Nikolett Lénárt, Zhaofa Wu, Miao Jing, Yulong Li, Attila I Gulyás, Ádám Dénes