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Publications

featured publications

  • Identifying the role of NLRP3 inflammasome in stroke progression and outcome before recanalization.

    Cell reports. Medicine

    Authors: Maximilian Bellut, Alexander M Kollikowski, Marius L Vogt, Lukas Rossnagel, Ibrahim Hawwari, Bernardo S Franklin, Mirko Pham, Guido Stoll, Michael K Schuhmann

  • Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.

    Nature communications

    Authors: Yu C J Chey, Bassam Kashgari, Louise McLeod, Georgette A Radford, Linden J Gearing, Ruby E Dawson, Malvika Kharbanda, Joanne Lundy, Daniel Croagh, Charlotte Girard-Guyonvarc'h, Cem Gabay, Brooke A Pereira, David Herrmann, Paul Timpson, John W Finnie, Mohamed I Saad, Dharmesh D Bhuva, Bernardo S Franklin, Florian I Schmidt, Brendan J Jenkins

  • "Cruising together"-ASC specks and SAA, a perfect match in chronic inflammation.

    EMBO molecular medicine

    Authors: Salie Maasewerd, Bernardo Simoes Franklin

  • Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes.

    EMBO molecular medicine

    Authors: Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

  • Platelets in Kawasaki disease: mediators of vascular inflammation.

    Nature reviews. Rheumatology

    Authors: Magali Noval Rivas, Begüm Kocatürk, Bernardo S Franklin, Moshe Arditi

  • Pediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction.

    British journal of pharmacology

    Authors: David F Colón, Carlos W Wanderley, Walter M Turato, Vanessa F Borges, Marcelo Franchin, Fernanda V S Castanheira, Daniele Nascimento, Douglas Prado, Mikhael Haruo Fernandes de Lima, Leila C Volpon, Silvia K Kavaguti, Ana P Carlotti, Fabio Carmona, Bernardo S Franklin, Thiago M Cunha, Jose C Alves-Filho, Fernando Q Cunha

  • Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.

    JCI insight

    Authors: Begüm Kocatürk, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E Lane, Debbie Moreira, Shuang Chen, Michael C Fishbein, Rebecca A Porritt, Bernardo S Franklin, Magali Noval Rivas, Moshe Arditi

  • Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Lea Jenster, Lucas S Ribeiro, Bernardo S Franklin, Damien Bertheloot

  • Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion.

    Cell death & disease

    Authors: Laura Migliari Branco, Marcelo Pires Amaral, Henning Boekhoff, Ana Beatriz Figueiredo de Lima, Ingrid Sancho Farias, Silvia Lucena Lage, Gustavo José Silva Pereira, Bernardo Simões Franklin, Karina Ramalho Bortoluci

  • Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.

    EMBO molecular medicine

    Authors: Damien Bertheloot, Carlos Ws Wanderley, Ayda H Schneider, Lisa Dj Schiffelers, Jennifer D Wuerth, Jan Mp Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin