Cluster of Excellence ImmunoSensation²

ImmunoSensation² is a Cluster of Excellence at the University of Bonn funded by the German Research Foundation (DFG). We are dedicated to the study of innate immunity beyond the boundaries of classical immunology. We adress the immune system as a sensory organ for health, which we term the immune sensory system. We are immunologists, neurobiologists, systems biologists, biochemists, biophysicists and mathematicians from the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at the University of Bonn and the German Centre for Neurodegenerative Diseases (DZNE) of the Helmholtz Association.

Founded in 2012, ImmunoSensation² is currently in its eleventh year of funding. We continue to pursue our mission of innovative science in immunology. Further, we link immunology to other systems, such as the metabolic system and the nervous system. Ultimately, we want to better understand the intimate connection between the immune sensory system and human health and disease.

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News

News categories: Honors & Funding

Funding of €6.9 Million for Sepsis Research

13 Sept 2023 —Every year some 75,000 people die from bacterial blood poisoning, or sepsis, in Germany alone. Survivors of sepsis often struggle with secondary and concomitant conditions due to the resulting impairment of the immune system, the so called “Immunesuppression”. The International Center for Clinical Research (ICRC) at St. Anne's University Hospital (FNUSA) Brno (Czech Republic) has founded the research consortium “BEATSep”. HORIZON EUROPA is funding it with around 6,9 million euros over the next five years.

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News categories: Honors & Funding

Unraveling the role of NLRC5 in melanoma progression

7 Sept 2023 —Immunotherapies offer new perspectives in the treatment of cancer. Unfortunately, tumor immune-escape mechanisms limit their effectiveness on a long turn. The intracellular receptor NLRC5 impacts the regulation of tumor recognition by the immune system in melanoma and other entities and is hence at the core of a new research project by ImmunoSensation² member Dr. Nicole Glodde from the Institute of Experimental Oncology at the University Hospital Bonn. The project is funded by the German Hiege Foundation, providing 30.000 € over the period of one year.

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News categories: Publication

Spatial Transcriptomics-correlated Electron Microscopy

24 Aug 2023 —In response to injury, cells of the surrounding tissues alter their structures and their gene expression activities. Although tightly intertwined, these two parameters have only been observed separately, due to technical limitations. ImmunoSensation2 member Prof. Dr. Özgün Gökce and colleagues now found a way to monitor transcriptional and ultrastructural responses to injury at once, using Spatial Transcriptomics-correlated Electron Microscopy. The results have recently been published in Nature Communications.

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