—Rare genetic diseases can sometimes be recognized through facial features, such as characteristically shaped brows, nose or cheeks. Researchers of the Cluster of Excellence ImmunoSensation² have now trained software that uses portrait photos to better diagnose such diseases. The study has now been published in the journal "Nature Genetics".
—Prof. Matthias Geyer and his team, in collaboration with researchers at the University of Regensburg, have solved the structure of a central cellular inflammatory switch: NLRP3. Cryo Electron Microscopy (Cryo-EM) analysis revealed NLRP3 to form a decameric structure when incubated with the inhibitor CRID3 (Cytokine Release Inhibitory Drug 3). Identifying the CRID3 binding-site as well as solving the overall structure of…
—Cancer cells can constantly change and in this way evade the immune system. Prof. Dr. Michael Hölzel from the Institute of Experimental Oncology at the University of Bonn is developing an immunotherapy against black skin cancer: He wants to use "smart" immune cells to get a grip on the tumor cells that are currently trying to make themselves invisible. German Cancer Aid is funding the project with…
Alzheimer’s: Inflammatory markers conspicuous at an early stage
—Long before the onset of dementia, there is evidence for increased activity of the brain’s immune system. Researchers from the Cluster of Excellence ImmunoSensation² of the DZNE and Bonn University come to this conclusion based on a study of more than 1,000 older adults. To this end, various proteins were measured in the cerebrospinal fluid: They served as so-called biomarkers that indicate inflammatory processes of the nervous system. As it turned out, some of these molecules seem to be part of a…
—Researchers of ImmunoSensation² in cooperation with an international team have developed a method to generate embryo-like cell complexes from the stem cells of mice. The method provides new insights into embryonic development. In the medium term, it might also be suitable for developing tests for substances that could be harmful to fertility. The study has recently been published in Nature Communications.
Elvira Mass selected as EMBO Young Investigator junior scientist
—Prof. Elvira Mass, developmental biologist at the LIMES Institute of the University of Bonn and member of the Cluster of Excellence, will join the EMBO Young Investigator Program on 01.01.2022. The program supports selected young European scientists with outstanding achievements in the field of life sciences. The award is linked to a financial support of 15,000 €, which can be extended by up to 10,000 € per year. Prof. Elvira Mass and her team study the development and function…
CRC for Brown and Beige Fat Organ Crosstalk, Signaling and Energetics
—Worldwide, the number of overweight and obese patients is increasing, and consequently diabetes and cardiovascular disease. Obesity is also a risk factor for developing severe Covid19. In the Transregional Collaborative Research Centre (CRC) 333 "Brown and Beige Fat Organ Crosstalk, Signaling and Energetics ( BATenergy)" researchers from the University of Bonn and the University Hospital Bonn, the University Medical…
Abemaciclib inhibits kinases involved in transcriptional regulation
—Abemaciclib is a widely used drug in the therapy of hormone-receptor positive (HR-positive) and human epidermal growth factor receptor negative (HER2-negative) advanced breast cancer. The drug functions as a direct inhibitor of cyclin-dependent kinases 4 and 6 (Cdk4/Cdk6). Both kinases are responsible for the deactivation of retinoblastoma protein (Rb) by phosphorylation. Until its deactivation, Rb prevents cell…
Cerebral dysfunctions caused by sepsis during aging
—Sepsis occurs when the body's own immune reactions against an infection inflicts damage to its own organs and tissues. Such systemic inflammation is a life-threatening condition and one of the most severe complications of infectious diseases. It may be caused by bacteria, viruses, fungi or parasites.
Systemic inflammations caused by Sepsis may induce an acute cerebral dysfunction known as sepsis- associated encephalopathy (SAE). Recent data from intensive care units show, that half of all patients…
