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featured publications

  • Potent induction of trained immunity by β-glucans.

    Frontiers in immunology

    Authors: Patricia Vuscan, Brenda Kischkel, Aikaterini Hatzioannou, Efrosyni Markaki, Andrei Sarlea, Maria Tintoré, Jordi Cuñé, Panayotis Verginis, Carlos de Lecea, Triantafyllos Chavakis, Leo A B Joosten, Mihai G Netea

  • Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery.

    Clinical immunology (Orlando, Fla.)

    Authors: Ilayda Baydemir, Elisabeth A Dulfer, Mihai G Netea, Jorge Domínguez-Andrés

  • Sex-biased genetic regulation of inflammatory proteins in the Dutch population.

    BMC genomics

    Authors: Collins K Boahen, Hannah Abee, Isis Ricaño Ponce, Leo A B Joosten, Mihai G Netea, Vinod Kumar

  • MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells.

    The Journal of clinical investigation

    Authors: Rutger J Röring, Priya A Debisarun, Javier Botey-Bataller, Tsz Kin Suen, Ozlem Bulut, Gizem Kilic, Valerie Acm Koeken, Andrei Sarlea, Harsh Bahrar, Helga Dijkstra, Heidi Lemmers, Katharina L Gössling, Nadine Rüchel, Philipp N Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Yavuz Ariyurek, Emile J de Meijer, Susan L Kloet, Jaap Ten Oever, Katarzyna Placek, Yang Li, Mihai G Netea

  • A CO sensing module modulates β-1,3-glucan exposure in .

    mBio

    Authors: Gabriela M Avelar, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Corin Liddle, Alejandra V Rodriguez Rondon, Ann-Kristin Kaune, Sophie Shaw, Corinne Maufrais, Natacha Sertour, Judith M Bain, Daniel E Larcombe, Leandro J de Assis, Mihai G Netea, Carol A Munro, Delma S Childers, Lars P Erwig, Gordon D Brown, Neil A R Gow, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Alistair J P Brown

  • Soluble urate-induced effects on cytokine production in vitro - Assessment of methodologies and cell types.

    Cytokine

    Authors: Ruiqi Liu, Viola Klück, Brenda Kischkel, Helin Tercan, Mihai G Netea, Tania O Crişan, Leo A B Joosten

  • Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.

    Journal of the American Heart Association

    Authors: Helin Tercan, Benjamin C Cossins, Rosanne C van Deuren, Joost H W Rutten, Leo A B Joosten, Mihai G Netea, Alexander Hoischen, Siroon Bekkering, Niels P Riksen

  • Intermediate monocytes are associated with the first major adverse cardiovascular event in patients with stable coronary artery disease.

    International journal of cardiology

    Authors: Mihaela I Dregoesc, Adrian B Țigu, Siroon Bekkering, Charlotte D C C van der Heijden, Laura Rodwell, Sorana D Bolboacă, Leo A B Joosten, Mihai G Netea, Niels P Riksen, Adrian C Iancu

  • Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity.

    Immunity

    Authors: Simone J C F M Moorlag, Lukas Folkman, Rob Ter Horst, Thomas Krausgruber, Daniele Barreca, Linda C Schuster, Victoria Fife, Vasiliki Matzaraki, Wenchao Li, Stephan Reichl, Vera P Mourits, Valerie A C M Koeken, L Charlotte J de Bree, Helga Dijkstra, Heidi Lemmers, Bram van Cranenbroek, Esther van Rijssen, Hans J P M Koenen, Irma Joosten, Cheng-Jian Xu, Yang Li, Leo A B Joosten, Reinout van Crevel, Mihai G Netea, Christoph Bock

  • Host genetic regulation of human gut microbial structural variation.

    Nature

    Authors: Daria V Zhernakova, Daoming Wang, Lei Liu, Sergio Andreu-Sánchez, Yue Zhang, Angel J Ruiz-Moreno, Haoran Peng, Niels Plomp, Ángela Del Castillo-Izquierdo, Ranko Gacesa, Esteban A Lopera-Maya, Godfrey S Temba, Vesla I Kullaya, Sander S van Leeuwen, Ramnik J Xavier, Quirijn de Mast, Leo A B Joosten, Niels P Riksen, Joost H W Rutten, Mihai G Netea, Serena Sanna, Cisca Wijmenga, Rinse K Weersma, Alexandra Zhernakova, Hermie J M Harmsen, Jingyuan Fu