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featured publications

  • Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19.

    Respiratory research

    Authors: Emma J Kooistra, Kilian Dahm, Antonius E van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L Smeets, Sjef van der Velde, Maarten J W van den Berg, Johannes G van der Hoeven, Anna C Aschenbrenner, Joachim L Schultze, Thomas Ulas, Matthijs Kox, Peter Pickkers

  • Fighting Post-COVID and ME/CFS - development of curative therapies.

    Frontiers in medicine

    Authors: Carmen Scheibenbogen, Judith Theresia Bellmann-Strobl, Cornelia Heindrich, Kirsten Wittke, Elisa Stein, Christiana Franke, Harald Prüss, Hannah Preßler, Marie-Luise Machule, Heinrich Audebert, Carsten Finke, Hanna Gwendolyn Zimmermann, Birgit Sawitzki, Christian Meisel, Markus Toelle, Anne Krueger, Anna C Aschenbrenner, Joachim L Schultze, Marc D Beyer, Markus Ralser, Michael Mülleder, Leif Erik Sander, Frank Konietschke, Friedemann Paul, Silvia Stojanov, Lisa Bruckert, Dennis M Hedderich, Franziska Knolle, Gabriela Riemekasten, Maria J G T Vehreschild, Oliver A Cornely, Uta Behrends, Susen Burock

  • huva: A human variation analysis framework to predict gene perturbation from population-scale multi-omics data.

    STAR protocols

    Authors: Anna C Aschenbrenner, Lorenzo Bonaguro

  • The 2000HIV study: Design, multi-omics methods and participant characteristics.

    Frontiers in immunology

    Authors: Wilhelm A J W Vos, Albert L Groenendijk, Marc J T Blaauw, Louise E van Eekeren, Adriana Navas, Maartje C P Cleophas, Nadira Vadaq, Vasiliki Matzaraki, Jéssica C Dos Santos, Elise M G Meeder, Janeri Fröberg, Gert Weijers, Yue Zhang, Jingyuan Fu, Rob Ter Horst, Christoph Bock, Rainer Knoll, Anna C Aschenbrenner, Joachim Schultze, Linos Vanderkerckhove, Talent Hwandih, Elizabeth R Wonderlich, Sai V Vemula, Mike van der Kolk, Sterre C P de Vet, Willem L Blok, Kees Brinkman, Casper Rokx, Arnt F A Schellekens, Quirijn de Mast, Leo A B Joosten, Marvin A H Berrevoets, Janneke E Stalenhoef, Annelies Verbon, Jan van Lunzen, Mihai G Netea, Andre J A M van der Ven

  • Human variation in population-wide gene expression data predicts gene perturbation phenotype.

    iScience

    Authors: Lorenzo Bonaguro, Jonas Schulte-Schrepping, Caterina Carraro, Laura L Sun, Benedikt Reiz, Ioanna Gemünd, Adem Saglam, Souad Rahmouni, Michel Georges, Peer Arts, Alexander Hoischen, Leo A B Joosten, Frank L van de Veerdonk, Mihai G Netea, Kristian Händler, Sach Mukherjee, Thomas Ulas, Joachim L Schultze, Anna C Aschenbrenner

  • A guide to systems-level immunomics.

    Nature immunology

    Authors: Lorenzo Bonaguro, Jonas Schulte-Schrepping, Thomas Ulas, Anna C Aschenbrenner, Marc Beyer, Joachim L Schultze

  • Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state.

    eLife

    Authors: Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, Barbara Gatto

  • Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.

    Frontiers in immunology

    Authors: Kevin Baßler, Wataru Fujii, Theodore S Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H Wadsworth, Travis K Hughes, Humberto J Ferreira, Emily Hinkley, Ines H Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J Theis, Dirk Skowasch, Joachim L Schultze

  • Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.

    Cell reports. Medicine

    Authors: Amit Frishberg, Emma Kooistra, Melanie Nuesch-Germano, Tal Pecht, Neta Milman, Nico Reusch, Stefanie Warnat-Herresthal, Niklas Bruse, Kristian Händler, Heidi Theis, Michael Kraut, Esther van Rijssen, Bram van Cranenbroek, Hans Jpm Koenen, Hidde Heesakkers, Mark van den Boogaard, Marieke Zegers, Peter Pickkers, Matthias Becker, Anna C Aschenbrenner, Thomas Ulas, Fabian J Theis, Shai S Shen-Orr, Joachim L Schultze, Matthijs Kox

  • Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

    Cell

    Authors: Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa T Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mülleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D Bülow, Henrik E Mei, Axel R Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A Mall, Sebastian Stricker, Jobst Röhmel, Victor M Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M Kuebler, Christian Meisel, Markus Ralser, Joachim L Schultze, Anna C Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E Sander, Nils Blüthgen, Birgit Sawitzki