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Publications

featured publications

  • Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.

    Frontiers in immunology

    Authors: Julia Wegner, Charlotte Hunkler, Katrin Ciupka, Gunther Hartmann, Martin Schlee

  • Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato

  • RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma.

    Journal of molecular cell biology

    Authors: Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Müller, Christian Hagen, Stephan Garbe, Rayk Behrendt, Martin Schlee, Jasper G van den Boorn, Eva Bartok, Marcel Renn, Gunther Hartmann

  • RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection.

    Molecular therapy. Nucleic acids

    Authors: Samira Marx, Beate M Kümmerer, Christian Grützner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann

  • MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

    Nature communications

    Authors: Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D'Rozario, Emily S Thomas, Henry Li, Clemens A Schmitt, Julie George, Roman K Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T Ullrich, Jens T Siveke, Kadoaki Ohashi, Martin Schlee, Martin L Sos

  • An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.

    Scientific reports

    Authors: Julia Wegner, Thomas Zillinger, Thais Marina Schlee-Guimaraes, Eva Bartok, Martin Schlee

  • DPP9 holds all the CARD8s for inflammasome regulation.

    Immunity

    Authors: Julia Wegner, Alexander Kirchhoff, Martin Schlee

  • The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis.

    Signal transduction and targeted therapy

    Authors: Anna-Maria Herzner, Martin Schlee, Eva Bartok

  • Top publication

    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.

    Immunity

    Authors: Thomas Ostendorf, Thomas Zillinger, Katarzyna Andryka, Thais Marina Schlee-Guimaraes, Saskia Schmitz, Samira Marx, Kübra Bayrak, Rebecca Linke, Sarah Salgert, Julia Wegner, Tatjana Grasser, Sonja Bauersachs, Leon Soltesz, Marc P Hübner, Maximilian Nastaly, Christoph Coch, Matthias Kettwig, Ingo Roehl, Marco Henneke, Achim Hoerauf, Winfried Barchet, Jutta Gärtner, Martin Schlee, Gunther Hartmann, Eva Bartok

  • Human TLR8 Senses RNA From -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells.

    Frontiers in immunology

    Authors: Christoph Coch, Benjamin Hommertgen, Thomas Zillinger, Juliane Daßler-Plenker, Bastian Putschli, Maximilian Nastaly, Beate M Kümmerer, Johanna F Scheunemann, Beatrix Schumak, Sabine Specht, Martin Schlee, Winfried Barchet, Achim Hoerauf, Eva Bartok, Gunther Hartmann