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  • Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release.

    Nature communications

    Authors: Sarah Rösing, Fabian Ullrich, Susann Meisterfeld, Franziska Schmidt, Laura Mlitzko, Marijana Croon, Ryan G Nattrass, Nadia Eberl, Julia Mahlberg, Martin Schlee, Anja Wieland, Philipp Simon, Daniel Hilbig, Ulrike Reuner, Alexander Rapp, Julia Bremser, Peter Mirtschink, Stephan Drukewitz, Thomas Zillinger, Stefan Beissert, Katrin Paeschke, Gunther Hartmann, Aleksandra Trifunovic, Eva Bartok, Claudia Günther

  • Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

  • Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells.

    International journal of molecular sciences

    Authors: Adham Abuelola Mohamed, Sofía Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G Brooks, Martin Schlee

  • Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.

    Frontiers in immunology

    Authors: Julia Wegner, Charlotte Hunkler, Katrin Ciupka, Gunther Hartmann, Martin Schlee

  • Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato

  • RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma.

    Journal of molecular cell biology

    Authors: Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Müller, Christian Hagen, Stephan Garbe, Rayk Behrendt, Martin Schlee, Jasper G van den Boorn, Eva Bartok, Marcel Renn, Gunther Hartmann

  • RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection.

    Molecular therapy. Nucleic acids

    Authors: Samira Marx, Beate M Kümmerer, Christian Grützner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann

  • MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

    Nature communications

    Authors: Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D'Rozario, Emily S Thomas, Henry Li, Clemens A Schmitt, Julie George, Roman K Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T Ullrich, Jens T Siveke, Kadoaki Ohashi, Martin Schlee, Martin L Sos

  • An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.

    Scientific reports

    Authors: Julia Wegner, Thomas Zillinger, Thais Marina Schlee-Guimaraes, Eva Bartok, Martin Schlee

  • DPP9 holds all the CARD8s for inflammasome regulation.

    Immunity

    Authors: Julia Wegner, Alexander Kirchhoff, Martin Schlee