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Publications

featured publications

  • Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.

    EMBO molecular medicine

    Authors: Damien Bertheloot, Carlos Ws Wanderley, Ayda H Schneider, Lisa Dj Schiffelers, Jennifer D Wuerth, Jan Mp Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin

  • Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus.

    Journal of clinical immunology

    Authors: Annemarie Steiner, Thomas Reygaerts, Alessandra Pontillo, Isabella Ceccherini, Jonas Moecking, Fiona Moghaddas, Sophia Davidson, Francesco Caroli, Alice Grossi, Fabio Fernandes Morato Castro, Jorge Kalil, Florian N Gohr, Florian I Schmidt, Eva Bartok, Thomas Zillinger, Gunther Hartmann, Matthias Geyer, Marco Gattorno, Leonardo Oliveira Mendonça, Seth L Masters

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann

  • The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity.

    PLoS pathogens

    Authors: Carlos Ramirez Alvarez, Carmon Kee, Ashwini Kumar Sharma, Leonie Thomas, Florian I Schmidt, Megan L Stanifer, Steeve Boulant, Carl Herrmann

  • Spike D614G - A Candidate Vaccine Antigen Against Covid-19.

    The New England journal of medicine

    Authors: Paul-Albert Koenig, Florian I Schmidt

  • Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.

    Cell reports

    Authors: Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, Rayhane Nchioua, Jan Hendrik Straub, Susanne Klute, Victoria Hunszinger, Fabian Zech, Caterina Prelli Bozzo, Wasim Aftab, Maria Hønholt Christensen, Carina Conzelmann, Janis Alexander Müller, Smitha Srinivasachar Badarinarayan, Christina Martina Stürzel, Ignasi Forne, Steffen Stenger, Karl-Klaus Conzelmann, Jan Münch, Florian Ingo Schmidt, Daniel Sauter, Axel Imhof, Frank Kirchhoff, Konstantin Maria Johannes Sparrer

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt

  • HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.

    Science (New York, N.Y.)

    Authors: Venkat Giri Magupalli, Roberto Negro, Yuzi Tian, Arthur V Hauenstein, Giuseppe Di Caprio, Wesley Skillern, Qiufang Deng, Pontus Orning, Hasan B Alam, Zoltan Maliga, Humayun Sharif, Jun Jacob Hu, Charles L Evavold, Jonathan C Kagan, Florian I Schmidt, Katherine A Fitzgerald, Tom Kirchhausen, Yongqing Li, Hao Wu

  • Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant.

    Rheumatology (Oxford, England)

    Authors: Troels Herlin, Sofie E Jørgensen, Christian Høst, Patrick S Mitchell, Maria Hønholt Christensen, Mira Laustsen, Dorthe A Larsen, Florian I Schmidt, Mette Christiansen, Trine H Mogensen

  • Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.

    PLoS pathogens

    Authors: Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff