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  • Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus.

    The Biochemical journal

    Authors: Charlotte Wijne, Pavana Suresh, Richard Dela Rosa, Luc van Oss, Sabine Normann, William McKibben, Florian I Schmidt, Hidde Ploegh

  • Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.

    Nature communications

    Authors: Yu C J Chey, Bassam Kashgari, Louise McLeod, Georgette A Radford, Linden J Gearing, Ruby E Dawson, Malvika Kharbanda, Joanne Lundy, Daniel Croagh, Charlotte Girard-Guyonvarc'h, Cem Gabay, Brooke A Pereira, David Herrmann, Paul Timpson, John W Finnie, Mohamed I Saad, Dharmesh D Bhuva, Bernardo S Franklin, Florian I Schmidt, Brendan J Jenkins

  • Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells.

    The EMBO journal

    Authors: Yonas M Tesfamariam, Maria H Christensen, Stefan Diehl, Tabea Klein, Julius M Lingnau, Sabine Normann, Elena Hagelauer, Miriam Herbert, Sophie Reimer, Richa P Joshi, Pujan Engels, Steffen Pritzl, Pietro Fontana, Thomas Zillinger, Gunther Hartmann, Anna Eis-Hübinger, Martin C Lam, Klaus J Walgenbach, Felix Meissner, Hao Wu, Florian I Schmidt

  • The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling.

    Nature communications

    Authors: Hanane Chamma, Soumyabrata Guha, Roger Junior Eloiflin, Adeline Augereau, Pierre Le Hars, Moritz Schüssler, Yasmine Messaoud-Nacer, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A Disyak, Clara Taffoni, Robin Charpentier, Zoé Husson, Emmanuel Valjent, Charlotte Andrieu-Soler, Eric Soler, Maria H Christensen, Søren R Paludan, Florian I Schmidt, Daniela Tropea, Karim Majzoub, Isabelle K Vila, Nadine Laguette

  • Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.

    Cell reports

    Authors: Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I Schmidt, Achim Hoerauf, Marc P Hübner

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • NIS-Seq enables cell-type-agnostic optical perturbation screening.

    Nature biotechnology

    Authors: Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Afraa Zackria, Salie Maasewerd, Marta Lovotti, Dorothee J Lapp, Florian N Gohr, Piotr Suwara, Jędrzej Świeżewski, Lukas Rossnagel, Fabienne Gobs, Maia Cristodaro, Lina Muhandes, Rayk Behrendt, Martin C Lam, Klaus J Walgenbach, Tobias Bald, Florian I Schmidt, Eicke Latz, Jonathan L Schmid-Burgk

  • Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

    Nature communications

    Authors: Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

  • Multi-omics characterization of the monkeypox virus infection.

    Nature communications

    Authors: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I Schmidt, Michael Way, Roland Rad, Andrew G Bowie, Ulrike Protzer, Andreas Pichlmair

  • Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.

    Nature

    Authors: Chao Wei, Wei Jiang, Ruiyu Wang, Haoyu Zhong, Huabin He, Xinwei Gao, Shilin Zhong, Fengting Yu, Qingchun Guo, Li Zhang, Lisa D J Schiffelers, Bin Zhou, Martin Trepel, Florian I Schmidt, Minmin Luo, Feng Shao