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featured publications

  • The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling.

    Nature communications

    Authors: Hanane Chamma, Soumyabrata Guha, Roger Junior Eloiflin, Adeline Augereau, Pierre Le Hars, Moritz Schüssler, Yasmine Messaoud-Nacer, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A Disyak, Clara Taffoni, Robin Charpentier, Zoé Husson, Emmanuel Valjent, Charlotte Andrieu-Soler, Eric Soler, Maria H Christensen, Søren R Paludan, Florian I Schmidt, Daniela Tropea, Karim Majzoub, Isabelle K Vila, Nadine Laguette

  • Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.

    Cell reports

    Authors: Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I Schmidt, Achim Hoerauf, Marc P Hübner

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • NIS-Seq enables cell-type-agnostic optical perturbation screening.

    Nature biotechnology

    Authors: Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Afraa Zackria, Salie Maasewerd, Marta Lovotti, Dorothee J Lapp, Florian N Gohr, Piotr Suwara, Jędrzej Świeżewski, Lukas Rossnagel, Fabienne Gobs, Maia Cristodaro, Lina Muhandes, Rayk Behrendt, Martin C Lam, Klaus J Walgenbach, Tobias Bald, Florian I Schmidt, Eicke Latz, Jonathan L Schmid-Burgk

  • Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

    Nature communications

    Authors: Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

  • Multi-omics characterization of the monkeypox virus infection.

    Nature communications

    Authors: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I Schmidt, Michael Way, Roland Rad, Andrew G Bowie, Ulrike Protzer, Andreas Pichlmair

  • Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.

    Nature

    Authors: Chao Wei, Wei Jiang, Ruiyu Wang, Haoyu Zhong, Huabin He, Xinwei Gao, Shilin Zhong, Fengting Yu, Qingchun Guo, Li Zhang, Lisa D J Schiffelers, Bin Zhou, Martin Trepel, Florian I Schmidt, Minmin Luo, Feng Shao

  • Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection.

    Nature communications

    Authors: Jonas D Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H Christensen, Joao A Paulo, Robin Antrobus, Steven P Gygi, Florian I Schmidt, Edward L Huttlin, Geoffrey L Smith, Michael P Weekes

  • Top publication

    Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

  • Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.

    The Journal of experimental medicine

    Authors: Kim Samirah Robinson, Gee Ann Toh, Muhammad Jasrie Firdaus, Khek Chian Tham, Pritisha Rozario, Chrissie K Lim, Ying Xiu Toh, Zhi Heng Lau, Sophie Charlotte Binder, Jacob Mayer, Carine Bonnard, Florian I Schmidt, John E A Common, Franklin L Zhong