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  • TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection.

    GMS infectious diseases

    Authors: Benedikt C Buerfent, Jesuthas Ajendra, Wiebke Stamminger, Fabian Gondorf, Achim Hoerauf, Marc P Hübner

  • Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis.

    Frontiers in immunology

    Authors: Jayagopi Surendar, Stefan J Frohberger, Indulekha Karunakaran, Vanessa Schmitt, Wiebke Stamminger, Anna-Lena Neumann, Christoph Wilhelm, Achim Hoerauf, Marc P Hübner

  • IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.

    PLoS neglected tropical diseases

    Authors: Frédéric Fercoq, Estelle Remion, Stefan J Frohberger, Nathaly Vallarino-Lhermitte, Achim Hoerauf, John Le Quesne, Frédéric Landmann, Marc P Hübner, Leo M Carlin, Coralie Martin

  • In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

    PLoS neglected tropical diseases

    Authors: Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf

  • Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation.

    Glia

    Authors: Indulekha Karunakaran, Shah Alam, Surendar Jayagopi, Stefan J Frohberger, Jan N Hansen, Janina Kuehlwein, Benedikt V Hölbling, Beatrix Schumak, Marc P Hübner, Markus H Gräler, Annett Halle, Gerhild van Echten-Deckert

  • Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.

    Parasites & vectors

    Authors: Stefan J Frohberger, Jesuthas Ajendra, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Benedikt C Buerfent, Katrin Gentil, Achim Hoerauf, Marc P Hübner

  • Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

    Science translational medicine

    Authors: Malina A Bakowski, Roohollah Kazem Shiroodi, Renhe Liu, Jason Olejniczak, Baiyuan Yang, Kerstin Gagaring, Hui Guo, Pamela M White, Laura Chappell, Alain Debec, Frédéric Landmann, Bettina Dubben, Franziska Lenz, Dominique Struever, Alexandra Ehrens, Stefan J Frohberger, Hanna Sjoberg, Nicolas Pionnier, Emma Murphy, John Archer, Andrew Steven, Valerine C Chunda, Fanny F Fombad, Patrick W Chounna, Abdel J Njouendou, Haelly M Metuge, Bertrand L Ndzeshang, Narcisse V Gandjui, Desmond N Akumtoh, Tayong D B Kwenti, Ashley K Woods, Sean B Joseph, Mitchell V Hull, Wen Xiong, Kelli L Kuhen, Mark J Taylor, Samuel Wanji, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Arnab K Chatterjee, Jason Roland, Matt S Tremblay, Peter G Schultz, William Sullivan, Xin-Jie Chu, H Michael Petrassi, Case W McNamara

  • Preclinical development of an oral anti- macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.

    Science translational medicine

    Authors: Mark J Taylor, Thomas W von Geldern, Louise Ford, Marc P Hübner, Kennan Marsh, Kelly L Johnston, Hanna T Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E Tyrer, Rachel H Clare, Darren A N Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly M Metuge, Valerinne C Chunda, Patrick W Ndongmo Chounna, Abdel J Njouendou, Fanny F Fombad, Robert Carr, Howard E Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J Kempf, Joseph D Turner, Stephen A Ward

  • Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

    PLoS neglected tropical diseases

    Authors: Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf

  • Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

    Journal of medicinal chemistry

    Authors: Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Yi Xia, David S Carter, Pamela W Berry, Jason Halladay, Fernando Rock, Rianna Stefanakis, Eric Easom, Jacob J Plattner, Louise Ford, Kelly L Johnston, Darren A N Cook, Rachel Clare, Andrew Cassidy, Laura Myhill, Hayley Tyrer, Joanne Gamble, Ana F Guimaraes, Andrew Steven, Franziska Lenz, Alexandra Ehrens, Stefan J Frohberger, Marianne Koschel, Achim Hoerauf, Marc P Hübner, Case W McNamara, Malina A Bakowski, Joseph D Turner, Mark J Taylor, Stephen A Ward