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featured publications

  • Polygenic scores as modifiers in Mendelian diseases.

    Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V

    Authors: Axel Schmidt, Kerstin U Ludwig, Henrike O Heyne

  • Large-scale SARS-CoV-2 sequencing indicates prior community circulation of the viral strain associated with Germany's largest meat processing plant.

    Scientific reports

    Authors: Jessica Nicolai, Abigail J Miller, Naja Hahn, Julia Fazaal, Anne Bunte, Janine Silvery, Marian Rosenstengel, Per Hoffmann, Kerstin U Ludwig, Carsten Tiemann, Laura E Rose, Alexander T Dilthey

  • Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.

    Human molecular genetics

    Authors: Kyle Dack, Kerstin U Ludwig, Evie Stergiakouli, Jonathan Sandy, Sethlina Aryee, George Davey Smith, Amy Davies, Yvonne Wren, Gemma C Sharp, Kerry Humphries, Elisabeth Mangold, Lucy Goudswaard, Karen Ho, Tom Dudding, Sarah J Lewis

  • Bonn: Prof. Dr. rer. nat. Kerstin U. Ludwig W2-Professur Immungenetik.

    Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V

    Authors: Kerstin U Ludwig

  • Combining genetic and single-cell expression data reveals cell types and novel candidate genes for orofacial clefting.

    Scientific reports

    Authors: Anna Siewert, Simone Hoeland, Elisabeth Mangold, Kerstin U Ludwig

  • Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation.

    Clinical epigenetics

    Authors: Laura K Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T Lawlor, Kathrin E Witzke, Barbara Sitek, Steven A Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T Siveke

  • Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates in Disease Formation.

    Biomolecules

    Authors: Ricarda Köllges, Jil Stegmann, Sophia Schneider, Lea Waffenschmidt, Julia Fazaal, Katinka Breuer, Alina C Hilger, Gabriel C Dworschak, Enrico Mingardo, Wolfgang Rösch, Aybike Hofmann, Claudia Neissner, Anne-Karolin Ebert, Raimund Stein, Nina Younsi, Karin Hirsch-Koch, Eberhard Schmiedeke, Nadine Zwink, Ekkehart Jenetzky, Holger Thiele, Kerstin U Ludwig, Heiko Reutter

  • Predicting the pathogenicity of missense variants using features derived from AlphaFold2.

    Bioinformatics (Oxford, England)

    Authors: Axel Schmidt, Sebastian Röner, Karola Mai, Hannah Klinkhammer, Martin Kircher, Kerstin U Ludwig

  • Analysis of candidate genes for cleft lip ± cleft palate using murine single-cell expression data.

    Frontiers in cell and developmental biology

    Authors: Anna Siewert, Benedikt Reiz, Carina Krug, Julia Heggemann, Elisabeth Mangold, Henning Dickten, Kerstin U Ludwig

  • Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores.

    Molecular genetics & genomic medicine

    Authors: Nina Ishorst, Leonie Henschel, Frederic Thieme, Dmitriy Drichel, Sugirthan Sivalingam, Sarah L Mehrem, Ariane C Fechtner, Julia Fazaal, Julia Welzenbach, André Heimbach, Carlo Maj, Oleg Borisov, Jonas Hausen, Ruth Raff, Alexander Hoischen, Michael Dixon, Alvaro Rada-Iglesias, Michaela Bartusel, Augusto Rojas-Martinez, Khalid Aldhorae, Bert Braumann, Teresa Kruse, Christian Kirschneck, Gerrit Spanier, Heiko Reutter, Stefanie Nowak, Lina Gölz, Michael Knapp, Andreas Buness, Peter Krawitz, Markus M Nöthen, Michael Nothnagel, Tim Becker, Kerstin U Ludwig, Elisabeth Mangold