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featured publications

  • Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes.

    Cell reports

    Authors: Lingjia Kong, Simone J C F M Moorlag, Ariel Lefkovith, Bihua Li, Vasiliki Matzaraki, Liesbeth van Emst, Heather A Kang, Isabel Latorre, Martin Jaeger, Leo A B Joosten, Mihai G Netea, Ramnik J Xavier

  • Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease.

    Blood

    Authors: Raffaella Molteni, Riccardo Biavasco, Davide Stefanoni, Travis Nemkov, Jorge Domínguez-Andrés, Rob J Arts, Ivan Merelli, Davide Mazza, Samuel Zambrano, Maddalena Panigada, Eleonora Cantoni, Isak W Tengesdal, Philippe Maksud, Francesco Piras, Daniela Cesana, Laura Cassina, Gianfranco Distefano, Alessia Loffreda, Daniela Gnani, Giacomo De Luca, Alessandro Tomelleri, Corrado Campochiaro, Leo A B Joosten, Charles A Dinarello, Anna Kajaste-Rudnitski, Julien Haroche, Simone Cardaci, Simone Cenci, Lorenzo Dagna, Claudio Doglioni, Marina Ferrarini, Elisabetta Ferrero, Alessandra Boletta, Angelo D'Alessandro, Eugenio Montini, Mihai G Netea, Giulio Cavalli

  • Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.

    Frontiers in immunology

    Authors: Jose Manuel Sánchez-Maldonado, Rafael Cáliz, Miguel Ángel López-Nevot, Antonio José Cabrera-Serrano, Ana Moñiz-Díez, Helena Canhão, Rob Ter Horst, Luca Quartuccio, Signe B Sorensen, Bente Glintborg, Merete L Hetland, Ileana Filipescu, Eva Pérez-Pampin, Pablo Conesa-Zamora, Jerzy Swierkot, Alfons A den Broeder, Salvatore De Vita, Eva Rabing Brix Petersen, Yang Li, Miguel A Ferrer, Alejandro Escudero, Mihai G Netea, Marieke J H Coenen, Vibeke Andersen, João E Fonseca, Manuel Jurado, Katarzyna Bogunia-Kubik, Eduardo Collantes, Juan Sainz

  • Induction of trained immunity by influenza vaccination - impact on COVID-19.

    PLoS pathogens

    Authors: Priya A Debisarun, Katharina L Gössling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Rüchel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A C M Koeken, Jorge Domínguez-Andrés, Simone J C F M Moorlag, Esther Taks, Philipp N Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Jaap Ten Oever, Reinout van Crevel, Yang Li, Mihai G Netea

  • In response to the Letter to the Editor by Ould Setti and Ould Setti RE: 'Non-specific Effects of vaccines and stunting: Timing May Be Essential'.

    EBioMedicine

    Authors: Mike L T Berendsen, Jeroen Smits, Mihai G Netea, Andre van der Ven

  • Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme.

    Proceedings of the National Academy of Sciences of the United States of America

    Authors: Elisa Jentho, Cristian Ruiz-Moreno, Boris Novakovic, Ioannis Kourtzelis, Wout L Megchelenbrink, Rui Martins, Triantafyllos Chavakis, Miguel P Soares, Lydia Kalafati, Joel Guerra, Franziska Roestel, Peter Bohm, Maren Godmann, Tatyana Grinenko, Anne Eugster, Martina Beretta, Leo A B Joosten, Mihai G Netea, Michael Bauer, Hendrik G Stunnenberg, Sebastian Weis

  • Top publication

    Transmission of trained immunity and heterologous resistance to infections across generations.

    Nature immunology

    Authors: Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Händler, Heidi Theis, Marc Beyer, Jos W M van der Meer, Leo A B Joosten, Jörn Walter, Joachim L Schultze, Thierry Roger, Evangelos J Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G Netea

  • Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia.

    Journal of leukocyte biology

    Authors: Anaísa V Ferreira, Rienke F Uijen, Ozlem Bulut, Marien I de Jonge, Jorge Domínguez-Andrés, Mihai G Netea

  • The epigenetic ghost of infections past.

    Nature reviews. Immunology

    Authors: Mihai G Netea

  • Trained Immunity as a Preventive Measure for Surgical Site Infections.

    Clinical microbiology reviews

    Authors: Lieke Ter Steeg, Jorge Domínguez-Andrés, Mihai G Netea, Leo A B Joosten, Reinout van Crevel