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Featured publications

  • Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.

    EMBO reports

    Authors: Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Felix Meissner, Rubén Fernández-Busnadiego, Dieter Edbauer

  • The emerging role of mass spectrometry-based proteomics in drug discovery.

    Nature reviews. Drug discovery

    Authors: Felix Meissner, Jennifer Geddes-McAlister, Matthias Mann, Marcus Bantscheff

  • Congenital deficiency reveals critical role of ISG15 in skin homeostasis.

    The Journal of clinical investigation

    Authors: Muhammad Nasir Hayat Malik, Syed Fakhar-Ul-Hassnain Waqas, Jana Zeitvogel, Jingyuan Cheng, Robert Geffers, Zeinab Abu-Elbaha Gouda, Ahmed Mahrous Elsaman, Ahmed R Radwan, Matthias Schefzyk, Peter Braubach, Bernd Auber, Ruth Olmer, Mathias Müsken, Lennart M Roesner, Gisa Gerold, Sven Schuchardt, Sylvia Merkert, Ulrich Martin, Felix Meissner, Thomas Werfel, Frank Pessler

  • Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment.

    Nature cancer

    Authors: Chiara Falcomatà, Stefanie Bärthel, Sebastian A Widholz, Christian Schneeweis, Juan José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J Swietlik, Jing-Yuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Zukowska, Angelica Arenas Vargas, Woo Hyun Paik, Moritz Jesinghaus, Katja Steiger, Roman Maresch, Rupert Öllinger, Tim Ammon, Olga Baranov, Maria S Robles, Julia Rechenberger, Bernhard Kuster, Felix Meissner, Maximilian Reichert, Michael Flossdorf, Roland Rad, Marc Schmidt-Supprian, Günter Schneider, Dieter Saur

  • Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity.

    Life science alliance

    Authors: Irene Riera-Tur, Tillman Schäfer, Daniel Hornburg, Archana Mishra, Miguel da Silva Padilha, Lorena Fernández-Mosquera, Dennis Feigenbutz, Patrick Auer, Matthias Mann, Wolfgang Baumeister, Rüdiger Klein, Felix Meissner, Nuno Raimundo, Rubén Fernández-Busnadiego, Irina Dudanova

  • Identification of covalent modifications regulating immune signaling complex composition and phenotype.

    Molecular systems biology

    Authors: Annika Frauenstein, Stefan Ebner, Fynn M Hansen, Ankit Sinha, Kshiti Phulphagar, Kirby Swatek, Daniel Hornburg, Matthias Mann, Felix Meissner

  • Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis.

    Cell reports

    Authors: Kshiti Phulphagar, Lars I Kühn, Stefan Ebner, Annika Frauenstein, Jonathan J Swietlik, Jan Rieckmann, Felix Meissner

  • Interaction of 7SK with the Smn complex modulates snRNP production.

    Nature communications

    Authors: Changhe Ji, Jakob Bader, Pradhipa Ramanathan, Luisa Hennlein, Felix Meissner, Sibylle Jablonka, Matthias Mann, Utz Fischer, Michael Sendtner, Michael Briese

  • Cholesterol sensing by CD81 is important for hepatitis C virus entry.

    The Journal of biological chemistry

    Authors: Machaela Palor, Lenka Stejskal, Piya Mandal, Annasara Lenman, María Pía Alberione, Jared Kirui, Rebecca Moeller, Stefan Ebner, Felix Meissner, Gisa Gerold, Adrian J Shepherd, Joe Grove

  • Dynamics in protein translation sustaining T cell preparedness.

    Nature immunology

    Authors: Tobias Wolf, Wenjie Jin, Giada Zoppi, Ian A Vogel, Murodzhon Akhmedov, Christopher K E Bleck, Tim Beltraminelli, Jan C Rieckmann, Neftali J Ramirez, Marco Benevento, Samuele Notarbartolo, Dirk Bumann, Felix Meissner, Bodo Grimbacher, Matthias Mann, Antonio Lanzavecchia, Federica Sallusto, Ivo Kwee, Roger Geiger