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featured publications

  • Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.

    Nature medicine

    Authors: Godfrey S Temba, Tal Pecht, Vesla I Kullaya, Nadira Vadaq, Mary V Mosha, Thomas Ulas, Sneha Kanungo, Liesbeth van Emst, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elias Mafuru, Paolo Lionetti, Musa M Mhlanga, Andre J van der Ven, Duccio Cavalieri, Leo A B Joosten, Reginald A Kavishe, Blandina T Mmbaga, Joachim L Schultze, Mihai G Netea, Quirijn de Mast

  • Dolutegravir plus lamivudine downregulates cellular stress responses versus three-drug HIV Regimens.

    AIDS (London, England)

    Authors: Victoria Rios-Vazquez, Wilhelm A J W Vos, Marc J T Blaauw, Louise E Van Eekeren, Albert L Groenendijk, Adriana Navas, Nadira Vadaq, Leo A B Joosten, Mihai G Netea, Willem L Blok, Janneke E Stalenhoef, Lambert Van Den Heuvel, Andre J A M Van Der Ven, Jan Van Lunzen

  • Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination.

    Nature aging

    Authors: Wenchao Li, Zhenhua Zhang, Saumya Kumar, Javier Botey-Bataller, Martijn Zoodsma, Ali Ehsani, Qiuyao Zhan, Ahmed Alaswad, Liang Zhou, Inge Grondman, Valerie Koeken, Jian Yang, Gang Wang, Sonja Volland, Tania O Crişan, Leo A B Joosten, Thomas Illig, Cheng-Jian Xu, Mihai G Netea, Yang Li

  • Targeting mTOR in myeloid cells prevents infection-associated inflammation.

    iScience

    Authors: Yohana C Toner, Jazz Munitz, Geoffrey Prevot, Judit Morla-Folch, William Wang, Yuri van Elsas, Bram Priem, Jeroen Deckers, Tom Anbergen, Thijs J Beldman, Eliane E S Brechbühl, Muhammed D Aksu, Athanasios Ziogas, Sebastian A Sarlea, Mumin Ozturk, Zhenhua Zhang, Wenchao Li, Yang Li, Alexander Maier, Jessica C Fernandes, Glenn A O Cremers, Bas van Genabeek, Joost H C M Kreijtz, Esther Lutgens, Niels P Riksen, Henk M Janssen, Serge H M Söntjens, Freek J M Hoeben, Ewelina Kluza, Gagandeep Singh, Evangelos J Giamarellos-Bourboulis, Michael Schotsaert, Raphaël Duivenvoorden, Roy van der Meel, Leo A B Joosten, Lei Cai, Ryan E Temel, Zahi A Fayad, Musa M Mhlanga, Mandy M T van Leent, Abraham J P Teunissen, Mihai G Netea, Willem J M Mulder

  • Integrative analysis reveals the multilateral inflammatory mechanisms of CD14 monocytes in gout.

    Annals of the rheumatic diseases

    Authors: Ahmed Alaswad, Georgiana Cabău, Tania O Crişan, Liang Zhou, Martijn Zoodsma, Javier Botey-Bataller, Wenchao Li, Cristina Pamfil, Mihai G Netea, Tony Merriman, Cheng-Jian Xu, Yang Li, Leo A B Joosten

  • Innate immune training of osteoclastogenesis promotes inflammatory bone loss in mice.

    Developmental cell

    Authors: Nora Haacke, Hui Wang, Shu Yan, Marko Barovic, Xiaofei Li, Kosuke Nagai, Adelina Botezatu, Aikaterini Hatzioannou, Bettina Gercken, Giulia Trimaglio, Anisha U Shah, Jun Wang, Ling Ye, Mangesh T Jaykar, Martina Rauner, Ben Wielockx, Kyoung-Jin Chung, Mihai G Netea, Lydia Kalafati, George Hajishengallis, Triantafyllos Chavakis

  • Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH.

    BMC medicine

    Authors: Louise E van Eekeren, Nadira Vadaq, Marc J T Blaauw, Albert L Groenendijk, Wilhelm A J W Vos, Erni J Nelwan, Annelies Verbon, Janneke E Stalenhoef, Marvin A H Berrevoets, Jan van Lunzen, Mihai G Netea, Gert Weijers, Niels P Riksen, Joost H W Rutten, Quirijn de Mast, Eric T T L Tjwa, Leo A B Joosten, André J A M van der Ven

  • Is systemic dissemination of BCG following neonatal vaccination required for protection against M. tuberculosis?

    The Journal of infectious diseases

    Authors: Tobias R Kollmann, Nelly Amenyogbe, Frederik Schaltz-Buchholzer, Ole Bæk, James Campbell, David J Lynn, Anita J Campbell, Peter Aaby, Christine Stabell Benn, Mihai G Netea, Maziar Divangahi

  • Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.

    Nature nanotechnology

    Authors: Stijn R J Hofstraat, Tom Anbergen, Robby Zwolsman, Jeroen Deckers, Yuri van Elsas, Mirre M Trines, Iris Versteeg, Daniek Hoorn, Gijs W B Ros, Branca M Bartelet, Merel M A Hendrikx, Youssef B Darwish, Teun Kleuskens, Francisca Borges, Rianne J F Maas, Lars M Verhalle, Willem Tielemans, Pieter Vader, Olivier G de Jong, Tommaso Tabaglio, Dave Keng Boon Wee, Abraham J P Teunissen, Eliane Brechbühl, Henk M Janssen, P Michel Fransen, Anne de Dreu, David P Schrijver, Bram Priem, Yohana C Toner, Thijs J Beldman, Mihai G Netea, Willem J M Mulder, Ewelina Kluza, Roy van der Meel

  • Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production.

    Ticks and tick-borne diseases

    Authors: Michelle A E Brouwer, Zara Karami, Samuel T Keating, Hedwig Vrijmoeth, Heidi L M Lemmers, Helga Dijkstra, Frank L van de Veerdonk, Mihaela Lupse, Hadewych J M Ter Hofstede, Mihai G Netea, Leo A B Joosten