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featured publications

  • Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

    Cell metabolism

    Authors: Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A Virtanen, Alexander Pfeifer

  • Lack of Gα proteins in adipocytes attenuates diet-induced obesity.

    Molecular metabolism

    Authors: Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg

  • Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing.

    JCI insight

    Authors: Nadine Schall, Julian J Garcia, Hema Kalyanaraman, Shyamsundar Pal China, Jenna J Lee, Robert L Sah, Alexander Pfeifer, Renate B Pilz

  • Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β and β-adrenoceptor signalling.

    Molecular metabolism

    Authors: Sukanya Arcot Kannabiran, Dominic Gosejacob, Birte Niemann, Viacheslav O Nikolaev, Alexander Pfeifer

  • Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

    British journal of pharmacology

    Authors: Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg, Jonathan G Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M König, Christa E Müller

  • RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation.

    Molecular metabolism

    Authors: Katarina Klepac, JuHee Yang, Staffan Hildebrand, Alexander Pfeifer

  • The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity.

    International journal of molecular sciences

    Authors: Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell

  • A R-induced transcriptional deregulation in astrocytes: An in vitro study.

    Glia

    Authors: Isabel Paiva, Kévin Carvalho, Patrícia Santos, Lucrezia Cellai, Maria Angeliki S Pavlou, Gaurav Jain, Thorsten Gnad, Alexander Pfeifer, Didier Vieau, André Fischer, Luc Buée, Tiago F Outeiro, David Blum

  • cGMP manipulation in cardiometabolic disease: chances and challenges.

    Current opinion in cardiology

    Authors: Jens Jordan, Staffan Hildebrand, Alexander Pfeifer

  • Local anti-angiogenic therapy by magnet-assisted downregulation of SHP2 phosphatase.

    Journal of controlled release : official journal of the Controlled Release Society

    Authors: Sarah Rieck, Yvonn Heun, Alexandra Heidsieck, Olga Mykhaylyk, Alexander Pfeifer, Bernhard Gleich, Hanna Mannell, Daniela Wenzel