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  • Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.

    Molecular cell

    Authors: Eva Marie Pfeil, Julian Brands, Nicole Merten, Timo Vögtle, Maddalena Vescovo, Ulrike Rick, Ina-Maria Albrecht, Nina Heycke, Kouki Kawakami, Yuki Ono, Francois Marie Ngako Kadji, Suzune Hiratsuka, Junken Aoki, Felix Häberlein, Michaela Matthey, Jaspal Garg, Stephanie Hennen, Marie-Lise Jobin, Kerstin Seier, Davide Calebiro, Alexander Pfeifer, Akos Heinemann, Daniela Wenzel, Gabriele M König, Bernhard Nieswandt, Bernd K Fleischmann, Asuka Inoue, Katharina Simon, Evi Kostenis

  • Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

    Communications biology

    Authors: Miguel J Lobo, Laia Reverte-Salisa, Ying-Chi Chao, Andreas Koschinski, Frank Gesellchen, Gunasekaran Subramaniam, He Jiang, Samuel Pace, Natasha Larcom, Ester Paolocci, Alexander Pfeifer, Sara Zanivan, Manuela Zaccolo

  • Combination of phosphodiesterase-5-inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction.

    Liver international : official journal of the International Association for the Study of the Liver

    Authors: Frank E Uschner, Kathleen Glückert, Rafael Paternostro, Thorsten Gnad, Robert Schierwagen, Mattias Mandorfer, Fernando Magdaleno, Cristina Ortiz, Katharina Schwarzkopf, Patrick S Kamath, Carlo Alessandria, Christoph Boesecke, Alexander Pfeifer, Thomas Reiberger, Wolfgang Kreisel, Tilman Sauerbruch, Arnulf Ferlitsch, Jonel Trebicka, Sabine Klein

  • Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

    Cell metabolism

    Authors: Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A Virtanen, Alexander Pfeifer

  • Lack of Gα proteins in adipocytes attenuates diet-induced obesity.

    Molecular metabolism

    Authors: Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg

  • Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing.

    JCI insight

    Authors: Nadine Schall, Julian J Garcia, Hema Kalyanaraman, Shyamsundar Pal China, Jenna J Lee, Robert L Sah, Alexander Pfeifer, Renate B Pilz

  • Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β and β-adrenoceptor signalling.

    Molecular metabolism

    Authors: Sukanya Arcot Kannabiran, Dominic Gosejacob, Birte Niemann, Viacheslav O Nikolaev, Alexander Pfeifer

  • Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

    British journal of pharmacology

    Authors: Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg, Jonathan G Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M König, Christa E Müller

  • RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation.

    Molecular metabolism

    Authors: Katarina Klepac, JuHee Yang, Staffan Hildebrand, Alexander Pfeifer

  • The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity.

    International journal of molecular sciences

    Authors: Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell