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Publications

featured publications

  • Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β and β-adrenoceptor signalling.

    Molecular metabolism

    Authors: Sukanya Arcot Kannabiran, Dominic Gosejacob, Birte Niemann, Viacheslav O Nikolaev, Alexander Pfeifer

  • Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

    British journal of pharmacology

    Authors: Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg, Jonathan G Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M König, Christa E Müller

  • RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation.

    Molecular metabolism

    Authors: Katarina Klepac, JuHee Yang, Staffan Hildebrand, Alexander Pfeifer

  • The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity.

    International journal of molecular sciences

    Authors: Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell

  • A R-induced transcriptional deregulation in astrocytes: An in vitro study.

    Glia

    Authors: Isabel Paiva, Kévin Carvalho, Patrícia Santos, Lucrezia Cellai, Maria Angeliki S Pavlou, Gaurav Jain, Thorsten Gnad, Alexander Pfeifer, Didier Vieau, André Fischer, Luc Buée, Tiago F Outeiro, David Blum

  • cGMP manipulation in cardiometabolic disease: chances and challenges.

    Current opinion in cardiology

    Authors: Jens Jordan, Staffan Hildebrand, Alexander Pfeifer

  • Local anti-angiogenic therapy by magnet-assisted downregulation of SHP2 phosphatase.

    Journal of controlled release : official journal of the Controlled Release Society

    Authors: Sarah Rieck, Yvonn Heun, Alexandra Heidsieck, Olga Mykhaylyk, Alexander Pfeifer, Bernhard Gleich, Hanna Mannell, Daniela Wenzel

  • Top publication

    Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

    Immunity

    Authors: Lisa Schmidleithner, Yasser Thabet, Eva Schönfeld, Maren Köhne, Daniel Sommer, Zeinab Abdullah, Timothy Sadlon, Collins Osei-Sarpong, Kotha Subbaramaiah, Francesca Copperi, Kristian Haendler, Tamas Varga, Oliver Schanz, Svenja Bourry, Kevin Bassler, Wolfgang Krebs, Annika E Peters, Ann-Kathrin Baumgart, Maria Schneeweiss, Kathrin Klee, Susanne V Schmidt, Simone Nüssing, Jil Sander, Naganari Ohkura, Andreas Waha, Tim Sparwasser, F Thomas Wunderlich, Irmgard Förster, Thomas Ulas, Heike Weighardt, Shimon Sakaguchi, Alexander Pfeifer, Matthias Blüher, Andrew J Dannenberg, Nerea Ferreirós, Louis J Muglia, Claudia Wickenhauser, Simon C Barry, Joachim L Schultze, Marc Beyer

  • Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis.

    EBioMedicine

    Authors: Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Hübner, Simone Kreth, Ralf A Claus, Sebastian Weis, Luisa Ungelenk, Florian Krötz, Ulrich Pohl, Hanna Mannell

  • Direct targeting of Gα and Gα oncoproteins in cancer cells.

    Science signaling

    Authors: Suvi Annala, Xiaodong Feng, Naveen Shridhar, Funda Eryilmaz, Julian Patt, JuHee Yang, Eva M Pfeil, Rodolfo Daniel Cervantes-Villagrana, Asuka Inoue, Felix Häberlein, Tanja Slodczyk, Raphael Reher, Stefan Kehraus, Stefania Monteleone, Ramona Schrage, Nina Heycke, Ulrike Rick, Sandra Engel, Alexander Pfeifer, Peter Kolb, Gabriele König, Moritz Bünemann, Thomas Tüting, José Vázquez-Prado, J Silvio Gutkind, Evelyn Gaffal, Evi Kostenis