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  • Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.

    Molecular cell

    Authors: Eva Marie Pfeil, Julian Brands, Nicole Merten, Timo Vögtle, Maddalena Vescovo, Ulrike Rick, Ina-Maria Albrecht, Nina Heycke, Kouki Kawakami, Yuki Ono, Francois Marie Ngako Kadji, Suzune Hiratsuka, Junken Aoki, Felix Häberlein, Michaela Matthey, Jaspal Garg, Stephanie Hennen, Marie-Lise Jobin, Kerstin Seier, Davide Calebiro, Alexander Pfeifer, Akos Heinemann, Daniela Wenzel, Gabriele M König, Bernhard Nieswandt, Bernd K Fleischmann, Asuka Inoue, Katharina Simon, Evi Kostenis

  • Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα Protein Inhibitors in Biological Samples.

    Frontiers in chemistry

    Authors: Markus Kuschak, Jonathan G Schlegel, Marion Schneider, Stefan Kehraus, Jan H Voss, Alexander Seidinger, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Gabriele M König, Christa E Müller

  • Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gα -Protein Ligands.

    Chemistry (Weinheim an der Bergstrasse, Germany)

    Authors: Jim Küppers, Tobias Benkel, Suvi Annala, Kenichi Kimura, Lisa Reinelt, Bernd K Fleischmann, Evi Kostenis, Michael Gütschow

  • Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.

    Cell stem cell

    Authors: Jan W Buikema, Soah Lee, William R Goodyer, Renee G Maas, Orlando Chirikian, Guang Li, Yi Miao, Sharon L Paige, Daniel Lee, Haodi Wu, David T Paik, Siyeon Rhee, Lei Tian, Francisco X Galdos, Nazan Puluca, Benjamin Beyersdorf, James Hu, Aimee Beck, Sneha Venkamatran, Srilatha Swami, Paul Wijnker, Maike Schuldt, Larissa M Dorsch, Alain van Mil, Kristy Red-Horse, Joy Y Wu, Caroline Geisen, Michael Hesse, Vahid Serpooshan, Stefan Jovinge, Bernd K Fleischmann, Pieter A Doevendans, Jolanda van der Velden, K Christopher Garcia, Joseph C Wu, Joost P G Sluijter, Sean M Wu

  • Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

    Cell metabolism

    Authors: Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A Virtanen, Alexander Pfeifer

  • Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

    British journal of pharmacology

    Authors: Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg, Jonathan G Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M König, Christa E Müller

  • In vivo detection of programmed cell death during mouse heart development.

    Cell death and differentiation

    Authors: Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C DeRuiter, Masayuki Miura, Bernd K Fleischmann, Michael Hesse

  • Optogenetic stimulation of G-signaling in the heart with high spatio-temporal precision.

    Nature communications

    Authors: Philipp Makowka, Tobias Bruegmann, Vanessa Dusend, Daniela Malan, Thomas Beiert, Michael Hesse, Bernd K Fleischmann, Philipp Sasse

  • Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility.

    PloS one

    Authors: René P Andrié, Thomas Beiert, Vincent Knappe, Markus Linhart, Florian Stöckigt, Alexandra M Klein, Alexander Ghanem, Indra Lübkemeier, Wilhelm Röll, Georg Nickenig, Bernd K Fleischmann, Jan W Schrickel