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featured publications

  • Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

    Cell

    Authors: Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore S Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik E Mei, Axel R Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bosquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph R Glösenkamp, Hans-Dieter Volk, Christine Goffinet, Markus Landthaler, Emanuel Wyler, Philipp Georg, Maria Schneider, Chantip Dang-Heine, Nick Neuwinger, Kai Kappert, Rudolf Tauber, Victor Corman, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Händler, Joachim L Schultze, Anna C Aschenbrenner, Yang Li, Jacob Nattermann, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander

  • NCX1 represents an ionic Na+ sensing mechanism in macrophages.

    PLoS biology

    Authors: Patrick Neubert, Arne Homann, David Wendelborn, Anna-Lorena Bär, Luka Krampert, Maximilian Trum, Agnes Schröder, Stefan Ebner, Andrea Weichselbaum, Valentin Schatz, Peter Linz, Roland Veelken, Jonas Schulte-Schrepping, Anna C Aschenbrenner, Thomas Quast, Christian Kurts, Sabrina Geisberger, Karl Kunzelmann, Karin Hammer, Katrina J Binger, Jens Titze, Dominik N Müller, Waldemar Kolanus, Joachim L Schultze, Stefan Wagner, Jonathan Jantsch

  • BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment.

    Cell host & microbe

    Authors: Branko Cirovic, L Charlotte J de Bree, Laszlo Groh, Bas A Blok, Joyce Chan, Walter J F M van der Velden, M E J Bremmers, Reinout van Crevel, Kristian Händler, Simone Picelli, Jonas Schulte-Schrepping, Kathrin Klee, Marije Oosting, Valerie A C M Koeken, Jakko van Ingen, Yang Li, Christine S Benn, Joachim L Schultze, Leo A B Joosten, Nigel Curtis, Mihai G Netea, Andreas Schlitzer

  • CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.

    The Journal of allergy and clinical immunology

    Authors: Lena Fischer-Riepe, Niklas Daber, Jonas Schulte-Schrepping, Bruna Caroline Véras De Carvalho, Antonella Russo, Michele Pohlen, Josephine Fischer, Achmet Imam Chasan, Marc Wolf, Thomas Ulas, Shirin Glander, Christian Schulz, Boris Skryabin, Andreas Wollbrink Dipl-Ing, Nadine Steingraeber, Christopher Stremmel, Megan Koehle, Florian Gärtner, Sabine Vettorazzi, Dirk Holzinger, Joachim Gross, Frank Rosenbauer, Monika Stoll, Silke Niemann, Jan Tuckermann, Joachim L Schultze, Johannes Roth, Katarzyna Barczyk-Kahlert

  • Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy.

    Oncoimmunology

    Authors: Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolás Gonzalo Núñez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C Holland, Peter Ellmark, Sara M Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues, Anna Dimberg

  • Defining trained immunity and its role in health and disease.

    Nature reviews. Immunology

    Authors: Mihai G Netea, Jorge Domínguez-Andrés, Luis B Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A B Joosten, Jos W M van der Meer, Musa M Mhlanga, Willem J M Mulder, Niels P Riksen, Andreas Schlitzer, Joachim L Schultze, Christine Stabell Benn, Joseph C Sun, Ramnik J Xavier, Eicke Latz

  • Top publication

    Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke.

    Nature neuroscience

    Authors: Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L Schultze, Frederic Geissmann, Ralf Stumm

  • Differential Gene Expression in Circulating CD14 Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis.

    Journal of clinical medicine

    Authors: Anke Liepelt, Philipp Hohlstein, Hendrik Gussen, Jia Xue, Anna C Aschenbrenner, Thomas Ulas, Lukas Buendgens, Klaudia T Warzecha, Matthias Bartneck, Tom Luedde, Christian Trautwein, Joachim L Schultze, Alexander Koch, Frank Tacke

  • Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics.

    iScience

    Authors: Stefanie Warnat-Herresthal, Konstantinos Perrakis, Bernd Taschler, Matthias Becker, Kevin Baßler, Marc Beyer, Patrick Günther, Jonas Schulte-Schrepping, Lea Seep, Kathrin Klee, Thomas Ulas, Torsten Haferlach, Sach Mukherjee, Joachim L Schultze