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featured publications

  • ConvexGating infers gating strategies from clusters in single cell cytometry data.

    Nature communications

    Authors: Vincent D Friedrich, Karola Mai, Thomas P Hofer, Elfriede Nößner, Lorenzo Bonaguro, Celia L Hartmann, Aleksej Frolov, Caterina Carraro, Doaa Hamada, Mehrnoush Hadaddzadeh Shakiba, Heidi Theis, Dalila Juliana Silva Ribeiro, Dagmar Wachten, F Thomas Wunderlich, Markus Scholz, Fabian J Theis, Matthias Becker, Marc D Beyer, Joachim L Schultze, Maren Büttner

  • Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

    Nature neuroscience

    Authors: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M B Breteler, N Ahmad Aziz, Paolo Salomoni

  • A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.

    Nature neuroscience

    Authors: Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A Müller, Merle Bublitz, Severin Filser, Lars Paeger, Brigitte Nuscher, Angelika Dannert, Sigrun Roeber, Veronica Pravata, Martina Schifferer, Joshua J Shrouder, Nathalie Schulz, Judit González-Gallego, Silvia Cappello, Thomas Misgeld, Nikolaus Plesnila, Eduardo Beltrán, Jochen Herms, Elena De Domenico, Marc D Beyer, Joachim L Schultze, Christian Haass, Stefan F Lichtenthaler, Caterina Carraro, Dominik Paquet

  • Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region.

    PLoS pathogens

    Authors: Suzanne D E Ruijten, Jéssica C Dos Santos, Victoria Rios-Vazquez, Adriana Navas, Hanneke Maas, Albert L Groenendijk, Marc J T Blaauw, Louise E van Eekeren, Wilhelm A J W Vos, Rainer Knoll, Manoj Kumar Gupta, Rob Ter Horst, Javier Botey-Bataller, Nienke van Unen, Yang Li, Anna C Aschenbrenner, Joachim L Schultze, Cheng-Jian Xu, Mihai G Netea, Andre J A M van der Ven, Vasiliki Matzaraki

  • Swarm Learning for the Detection of Middle Cerebral Artery Occlusion On CT Angiography.

    Clinical neuroradiology

    Authors: Julia K Harten, Soma Hansel, Dominik Creuzberg, Gianluca Brugnara, Daniel Kuetting, Mischa Uebachs, Johannes Weller, Gabor C Petzold, Franziska Dorn, Philipp Vollmuth, Anna C Aschenbrenner, Joachim L Schultze, Alexander Radbruch, Alexander Effland, Nils C Lehnen

  • The World Brain Health Forum: breaking silos for co-ordinated action.

    Nature reviews. Neurology

    Authors: Stéphanie Debette, Natalia S Rost, Siddharthan Chandran, Mathieu Vandenbulcke, Joachim L Schultze, Claudio L A Bassetti

  • Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework.

    Frontiers in digital health

    Authors: Marc Jacobs, Samad Goudarzi, Jan Stücke, Robin Röhm, Timo Kanninen, Tero Oinonen, Petra Ritter, Michael Schirner, Fabian Prasser, Arman Bhagwagar, Bernd Matzenbach, Hartmut Schultze, Joachim Schultze, Mathias Göschl, Henrik Matthies, Kenneth R Evans, Moyez Dharsee, Christian Stephan, Marvin Belz, Philip Gribbon, Katja Herzog, Chester Chen, David Ruau, Ittai Dayan, Adrish Sannyasi, Dieter Kranzlmüller, Naweiluo Zhou, Jens Warfsmann, Martin Hoffmann, Rudi Schmidt, Martin Hofmann-Apitius

  • Large-scale analysis of temporal gene expression variation in peripheral blood.

    Nature communications

    Authors: Neha Mishra, Franziska Kimmig, Doris Vandeputte, Valentina Talevi, Lindsey De Commer, Chloe Verspecht, Arnau Vich Vila, Julia S El-Sayed Moustafa, Lukasz Kreft, Alexander Botzki, Youssef El Darzi, Sebastian Proost, Lindsay Devolder, Dongmeng Wang, Joana P Bernardes, N Ahmad Aziz, Andre Franke, Stefan Schreiber, Emmanouil T Dermitzakis, Sara Vieira-Silva, Gwen Falony, Kerrin S Small, Monique M B Breteler, Joachim L Schultze, Jeroen Raes, Philip Rosenstiel

  • Enhanced TLR7-induced interferon responses in women living with HIV.

    Frontiers in immunology

    Authors: Alisa Huber, Nadira Vadaq, Albert L Groenendijk, Victoria Rios-Vazquez, Suzanne D E Ruijten, Rainer Knoll, Joost A H Martens, Adriana Navas, Vasiliki Matzaraki, Wilhelm A J W Vos, Marc J T Blaauw, Louise E van Eekeren, Maartje C P Jacobs-Cleophas, Anna C Aschenbrenner, Joachim L Schultze, Jan van Lunzen, Mihai G Netea, Andre J A M van der Ven, Leo A B Joosten, Jéssica C Dos Santos

  • Semantic alignment of the German Human Genome-Phenome Archive metadata model in Europe's genomics field.

    Scientific data

    Authors: Karoline Mauer, Anandhi Iyappan, Simon Parker, Bilge Sürün, Galina Tremper, Paul Menges, Léon Kuchenbecker, Koray Kirli, Joachim L Schultze, Sven Nahnsen, Thomas Ulas