Publications

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.

14/03/2022 Nature communications

Authors: Gizem Günes Günsel, Thomas M Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertüz, Niklas J Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C Pestoni, Stephanie L Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P Van Eeckhoutte, Özgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-López, Carlos M Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E Verleden, Bart Vanaudenaerde, Melanie Königshoff, Gunnar Dittmar, Ken R Bracke, Joachim L Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B Schiller, Marcus Conrad, Robert Schneider, Ali Önder Yildirim

Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States.

01/03/2022 Cells

Authors: Lena F Schimke, Alexandre H C Marques, Gabriela Crispim Baiocchi, Caroline Aliane de Souza Prado, Dennyson Leandro M Fonseca, Paula Paccielli Freire, Desirée Rodrigues Plaça, Igor Salerno Filgueiras, Ranieri Coelho Salgado, Gabriel Jansen-Marques, Antonio Edson Rocha Oliveira, Jean Pierre Schatzmann Peron, Gustavo Cabral-Miranda, José Alexandre Marzagão Barbuto, Niels Olsen Saraiva Camara, Vera Lúcia Garcia Calich, Hans D Ochs, Antonio Condino-Neto, Katherine A Overmyer, Joshua J Coon, Joseph Balnis, Ariel Jaitovich, Jonas Schulte-Schrepping, Thomas Ulas, Joachim L Schultze, Helder I Nakaya, Igor Jurisica, Otávio Cabral-Marques

Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.

10/02/2022 Journal of thrombosis and haemostasis : JTH

Authors: Godfrey S Temba, Nadira Vadaq, Jun Wan, Vesla Kullaya, Dana Huskens, Tal Pecht, Martin Jaeger, Collins K Boahen, Vasiliki Matzaraki, Wieteke Broeders, Leo A B Joosten, Sultana M H Faradz, Gibson Kibiki, Saskia Middeldorp, Duccio Cavalieri, Paolo Lionetti, Philip G de Groot, Joachim L Schultze, Mihai G Netea, Vinod Kumar, Bas de Laat, Blandina T Mmbaga, Andre J van der Ven, Mark Roest, Quirijn de Mast

Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'.

20/01/2022 Nature immunology

Authors: Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Händler, Heidi Theis, Marc Beyer, Jos W M van der Meer, Leo A B Joosten, Jörn Walter, Joachim L Schultze, Thierry Roger, Evangelos J Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G Netea

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

28/12/2021 Cell

Authors: Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa T Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mülleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D Bülow, Henrik E Mei, Axel R Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A Mall, Sebastian Stricker, Jobst Röhmel, Victor M Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M Kuebler, Christian Meisel, Markus Ralser, Joachim L Schultze, Anna C Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E Sander, Nils Blüthgen, Birgit Sawitzki

Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs.

16/12/2021 Nature communications

Authors: Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Lisa Holsten, Tatiana Hesse, Alexej Knaus, Yannick Riedel, Matthias Becker, Kristian Händler, Tarek Elmzzahi, Kevin Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Adem Saglam, Thomas Ulas, Anna C Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim L Schultze, Hubert Schorle

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.

07/12/2021 Nature cell biology

Authors: Julia P Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

27/11/2021 Cell

Authors: Daniel Wendisch, Oliver Dietrich, Tommaso Mari, Saskia von Stillfried, Ignacio L Ibarra, Mirja Mittermaier, Christin Mache, Robert Lorenz Chua, Rainer Knoll, Sara Timm, Sophia Brumhard, Tobias Krammer, Henrik Zauber, Anna Luisa Hiller, Anna Pascual-Reguant, Ronja Mothes, Roman David Bülow, Jessica Schulze, Alexander M Leipold, Sonja Djudjaj, Florian Erhard, Robert Geffers, Fabian Pott, Julia Kazmierski, Josefine Radke, Panagiotis Pergantis, Kevin Baßler, Claudia Conrad, Anna C Aschenbrenner, Birgit Sawitzki, Markus Landthaler, Emanuel Wyler, David Horst, Stefan Hippenstiel, Andreas Hocke, Frank L Heppner, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Susanne Herold, Sefer Elezkurtaj, Charlotte Thibeault, Martin Witzenrath, Clément Cochain, Norbert Suttorp, Christian Drosten, Christine Goffinet, Florian Kurth, Joachim L Schultze, Helena Radbruch, Matthias Ochs, Roland Eils, Holger Müller-Redetzky, Anja E Hauser, Malte D Luecken, Fabian J Theis, Christian Conrad, Thorsten Wolff, Peter Boor, Matthias Selbach, Antoine-Emmanuel Saliba, Leif Erik Sander

Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.

26/11/2021 The EMBO journal

Authors: Markus P Kummer, Christina Ising, Christiane Kummer, Heela Sarlus, Angelika Griep, Ana Vieira-Saecker, Stephanie Schwartz, Annett Halle, Matthias Brückner, Kristian Händler, Joachim L Schultze, Marc Beyer, Eicke Latz, Michael T Heneka

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.

28/10/2021 Cell metabolism

Authors: Sebastian Willenborg, David E Sanin, Alexander Jais, Xiaolei Ding, Thomas Ulas, Julian Nüchel, Milica Popović, Thomas MacVicar, Thomas Langer, Joachim L Schultze, Alexander Gerbaulet, Axel Roers, Edward J Pearce, Jens C Brüning, Aleksandra Trifunovic, Sabine A Eming