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featured publications

  • Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.

    Genome medicine

    Authors: Neha Mishra, Konrad Aden, Johanna I Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B Sørensen, Silja H Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A Lyons, Joachim L Schultze, Jörn Walter, Vibeke Andersen, Emmanouil T Dermitzakis, Stefan Schreiber, Philip Rosenstiel

  • A guide to systems-level immunomics.

    Nature immunology

    Authors: Lorenzo Bonaguro, Jonas Schulte-Schrepping, Thomas Ulas, Anna C Aschenbrenner, Marc Beyer, Joachim L Schultze

  • Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state.

    eLife

    Authors: Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, Barbara Gatto

  • The discovAIR project: a roadmap towards the Human Lung Cell Atlas.

    The European respiratory journal

    Authors: Malte D Luecken, Laure-Emmanuelle Zaragosi, Elo Madissoon, Lisa Sikkema, Alexandra B Firsova, Elena De Domenico, Louis Kümmerle, Adem Saglam, Marijn Berg, Aurore C A Gay, Janine Schniering, Christoph H Mayr, Xesús M Abalo, Ludvig Larsson, Alexandros Sountoulidis, Sarah A Teichmann, Karen van Eunen, Gerard H Koppelman, Kourosh Saeb-Parsy, Sylvie Leroy, Pippa Powell, Ugis Sarkans, Wim Timens, Joakim Lundeberg, Maarten van den Berge, Mats Nilsson, Peter Horváth, Jessica Denning, Irene Papatheodorou, Joachim L Schultze, Herbert B Schiller, Pascal Barbry, Ilya Petoukhov, Alexander V Misharin, Ian M Adcock, Michael von Papen, Fabian J Theis, Christos Samakovlis, Kerstin B Meyer, Martijn C Nawijn

  • Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

    Cell death and differentiation

    Authors: Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L Schultze, Javier Herrero, Paul O'Donnell, Agamemnon E Grigoriadis, Paolo Salomoni, Adrienne M Flanagan

  • Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.

    Frontiers in immunology

    Authors: Kevin Baßler, Wataru Fujii, Theodore S Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H Wadsworth, Travis K Hughes, Humberto J Ferreira, Emily Hinkley, Ines H Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J Theis, Dirk Skowasch, Joachim L Schultze

  • Swarm immunology: harnessing blockchain technology and artificial intelligence in human immunology.

    Nature reviews. Immunology

    Authors: Joachim L Schultze, Maren Büttner, Matthias Becker

  • Immune response in COVID-19: what is next?

    Cell death and differentiation

    Authors: Qing Li, Ying Wang, Qiang Sun, Jasmin Knopf, Martin Herrmann, Liangyu Lin, Jingting Jiang, Changshun Shao, Peishan Li, Xiaozhou He, Fei Hua, Zubiao Niu, Chaobing Ma, Yichao Zhu, Giuseppe Ippolito, Mauro Piacentini, Jerome Estaquier, Sonia Melino, Felix Daniel Weiss, Emanuele Andreano, Eicke Latz, Joachim L Schultze, Rino Rappuoli, Alberto Mantovani, Tak Wah Mak, Gerry Melino, Yufang Shi

  • Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.

    Cell reports. Medicine

    Authors: Amit Frishberg, Emma Kooistra, Melanie Nuesch-Germano, Tal Pecht, Neta Milman, Nico Reusch, Stefanie Warnat-Herresthal, Niklas Bruse, Kristian Händler, Heidi Theis, Michael Kraut, Esther van Rijssen, Bram van Cranenbroek, Hans Jpm Koenen, Hidde Heesakkers, Mark van den Boogaard, Marieke Zegers, Peter Pickkers, Matthias Becker, Anna C Aschenbrenner, Thomas Ulas, Fabian J Theis, Shai S Shen-Orr, Joachim L Schultze, Matthijs Kox

  • SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

    Molecular metabolism

    Authors: Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano