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featured publications

  • SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

    Cell

    Authors: Daniel Wendisch, Oliver Dietrich, Tommaso Mari, Saskia von Stillfried, Ignacio L Ibarra, Mirja Mittermaier, Christin Mache, Robert Lorenz Chua, Rainer Knoll, Sara Timm, Sophia Brumhard, Tobias Krammer, Henrik Zauber, Anna Luisa Hiller, Anna Pascual-Reguant, Ronja Mothes, Roman David Bülow, Jessica Schulze, Alexander M Leipold, Sonja Djudjaj, Florian Erhard, Robert Geffers, Fabian Pott, Julia Kazmierski, Josefine Radke, Panagiotis Pergantis, Kevin Baßler, Claudia Conrad, Anna C Aschenbrenner, Birgit Sawitzki, Markus Landthaler, Emanuel Wyler, David Horst, Stefan Hippenstiel, Andreas Hocke, Frank L Heppner, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Susanne Herold, Sefer Elezkurtaj, Charlotte Thibeault, Martin Witzenrath, Clément Cochain, Norbert Suttorp, Christian Drosten, Christine Goffinet, Florian Kurth, Joachim L Schultze, Helena Radbruch, Matthias Ochs, Roland Eils, Holger Müller-Redetzky, Anja E Hauser, Malte D Luecken, Fabian J Theis, Christian Conrad, Thorsten Wolff, Peter Boor, Matthias Selbach, Antoine-Emmanuel Saliba, Leif Erik Sander

  • Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.

    The EMBO journal

    Authors: Markus P Kummer, Christina Ising, Christiane Kummer, Heela Sarlus, Angelika Griep, Ana Vieira-Saecker, Stephanie Schwartz, Annett Halle, Matthias Brückner, Kristian Händler, Joachim L Schultze, Marc Beyer, Eicke Latz, Michael T Heneka

  • Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.

    Cell metabolism

    Authors: Sebastian Willenborg, David E Sanin, Alexander Jais, Xiaolei Ding, Thomas Ulas, Julian Nüchel, Milica Popović, Thomas MacVicar, Thomas Langer, Joachim L Schultze, Alexander Gerbaulet, Axel Roers, Edward J Pearce, Jens C Brüning, Aleksandra Trifunovic, Sabine A Eming

  • Top publication

    Transmission of trained immunity and heterologous resistance to infections across generations.

    Nature immunology

    Authors: Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Händler, Heidi Theis, Marc Beyer, Jos W M van der Meer, Leo A B Joosten, Jörn Walter, Joachim L Schultze, Thierry Roger, Evangelos J Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G Netea

  • Creld2 function during unfolded protein response is essential for liver metabolism homeostasis.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Authors: Paul Kern, Nora R Balzer, Nelli Blank, Cornelia Cygon, Klaus Wunderling, Franziska Bender, Alex Frolov, Jan-Peter Sowa, Lorenzo Bonaguro, Thomas Ulas, Mirka Homrich, Eva Kiermaier, Christoph Thiele, Joachim L Schultze, Ali Canbay, Reinhard Bauer, Elvira Mass

  • Alveolar macrophage transcriptomic profiling in COPD shows major lipid metabolism changes.

    ERJ open research

    Authors: Wataru Fujii, Theodore S Kapellos, Kevin Baßler, Kristian Händler, Lisa Holsten, Rainer Knoll, Stefanie Warnat-Herresthal, Marie Oestreich, Emily R Hinkley, Jan Hasenauer, Carmen Pizarro, Christoph Thiele, Anna C Aschenbrenner, Thomas Ulas, Dirk Skowasch, Joachim L Schultze

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann

  • Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation.

    Proceedings of the National Academy of Sciences of the United States of America

    Authors: Maria Embgenbroich, Hendrik J P van der Zande, Leonie Hussaarts, Jonas Schulte-Schrepping, Leonard R Pelgrom, Noemí García-Tardón, Laura Schlautmann, Isabel Stoetzel, Kristian Händler, Joost M Lambooij, Anna Zawistowska-Deniziak, Lisa Hoving, Karin de Ruiter, Marjolein Wijngaarden, Hanno Pijl, Ko Willems van Dijk, Bart Everts, Vanessa van Harmelen, Maria Yazdanbakhsh, Joachim L Schultze, Bruno Guigas, Sven Burgdorf

  • De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis.

    The EMBO journal

    Authors: Sara Zocher, Rupert W Overall, Gabriel Berdugo-Vega, Nicole Rund, Anne Karasinsky, Vijay S Adusumilli, Christina Steinhauer, Sina Scheibenstock, Kristian Händler, Joachim L Schultze, Federico Calegari, Gerd Kempermann

  • Monocytes and Macrophages in COVID-19.

    Frontiers in immunology

    Authors: Rainer Knoll, Joachim L Schultze, Jonas Schulte-Schrepping