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featured publications

  • How location and cellular signaling combine to activate the NLRP3 inflammasome.

    Cellular & molecular immunology

    Authors: Anil Akbal, Alesja Dernst, Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Eicke Latz

  • Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.

    Circulation

    Authors: Mohammed Rabiul Hosen, Philip Roger Goody, Andreas Zietzer, Xu Xiang, Sven Thomas Niepmann, Alexander Sedaghat, Vedat Tiyerili, Ramesh Chennupati, Joseph B Moore, Reinier A Boon, Shizuka Uchida, Jan-Malte Sinning, Sebastian Zimmer, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

  • Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.

    Nature communications

    Authors: Kai Markus Schneider, Antje Mohs, Wenfang Gui, Eric J C Galvez, Lena Susanna Candels, Lisa Hoenicke, Uthayakumar Muthukumarasamy, Christian H Holland, Carsten Elfers, Konrad Kilic, Carolin Victoria Schneider, Robert Schierwagen, Pavel Strnad, Theresa H Wirtz, Hanns-Ulrich Marschall, Eicke Latz, Benjamin Lelouvier, Julio Saez-Rodriguez, Willem de Vos, Till Strowig, Jonel Trebicka, Christian Trautwein

  • Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.

    Nature metabolism

    Authors: Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K Holm, Christian M Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller

  • Immune response in COVID-19: what is next?

    Cell death and differentiation

    Authors: Qing Li, Ying Wang, Qiang Sun, Jasmin Knopf, Martin Herrmann, Liangyu Lin, Jingting Jiang, Changshun Shao, Peishan Li, Xiaozhou He, Fei Hua, Zubiao Niu, Chaobing Ma, Yichao Zhu, Giuseppe Ippolito, Mauro Piacentini, Jerome Estaquier, Sonia Melino, Felix Daniel Weiss, Emanuele Andreano, Eicke Latz, Joachim L Schultze, Rino Rappuoli, Alberto Mantovani, Tak Wah Mak, Gerry Melino, Yufang Shi

  • Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination.

    The Journal of infectious diseases

    Authors: Gereon J Rieke, Kathrin van Bremen, Jenny Bischoff, Michael ToVinh, Malte B Monin, Stefan Schlabe, Jan Raabe, Kim M Kaiser, Claudia Finnemann, Alexandru Odainic, Anushka Kudaliyanage, Eicke Latz, Christian P Strassburg, Christoph Boesecke, Susanne V Schmidt, Benjamin Krämer, Jürgen K Rockstroh, Jacob Nattermann

  • Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.

    Science advances

    Authors: Inga V Hochheiser, Heide Behrmann, Gregor Hagelueken, Juan F Rodríguez-Alcázar, Anja Kopp, Eicke Latz, Elmar Behrmann, Matthias Geyer

  • Primary cilia and their effects on immune cell functions and metabolism: a model.

    Trends in immunology

    Authors: Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten

  • Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1.

    Respiratory research

    Authors: Konrad Peukert, Folkert Steinhagen, Mario Fox, Caroline Feuerborn, Susanne Schulz, Benjamin Seeliger, Patrick Schuss, Matthias Schneider, Stilla Frede, Andrea Sauer, Christian Putensen, Eicke Latz, Christoph Wilhelm, Christian Bode

  • Top publication

    Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.

    Nature

    Authors: Inga V Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer