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featured publications

  • Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.

    Nature immunology

    Authors: Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J Schunk, David Schmit, Rafael Kramann, Christina Körbel, Emmanuel Ampofo, Matthias W Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Günther Silbernagel, Martina Sester, Urban Sester, Gunter Aßmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D Menger, Lucia Rohrer, Winfried März, Michael Böhm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer

  • Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.

    Alzheimer's research & therapy

    Authors: Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T Heneka

  • Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.

    PLoS biology

    Authors: Matthew S J Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow, Thomas Ebert, Dieter Jahn, Karsten Hiller, Veit Hornung, Marcus Maurer, Florian I Schmidt, Ralf Gerhard, Eicke Latz

  • ATP-binding and hydrolysis of human NLRP3.

    Communications biology

    Authors: Rebecca Brinkschulte, David M Fußhöller, Florian Hoss, Juan F Rodríguez-Alcázar, Mario A Lauterbach, Carl-Christian Kolbe, Melanie Rauen, Semra Ince, Christian Herrmann, Eicke Latz, Matthias Geyer

  • Top publication

    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.

    The Journal of experimental medicine

    Authors: Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D Wuerth, Lisa D J Schiffelers, Yonas M Tesfamariam, Florian N Gohr, Laura Klein, Ines H Kaltheuner, Stefan Ebner, Dorothee J Lapp, Jacob Mayer, Jonas Moecking, Hidde L Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M Kümmerer, Florian I Schmidt

  • How location and cellular signaling combine to activate the NLRP3 inflammasome.

    Cellular & molecular immunology

    Authors: Anil Akbal, Alesja Dernst, Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Eicke Latz

  • Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.

    Nature communications

    Authors: Kai Markus Schneider, Antje Mohs, Wenfang Gui, Eric J C Galvez, Lena Susanna Candels, Lisa Hoenicke, Uthayakumar Muthukumarasamy, Christian H Holland, Carsten Elfers, Konrad Kilic, Carolin Victoria Schneider, Robert Schierwagen, Pavel Strnad, Theresa H Wirtz, Hanns-Ulrich Marschall, Eicke Latz, Benjamin Lelouvier, Julio Saez-Rodriguez, Willem de Vos, Till Strowig, Jonel Trebicka, Christian Trautwein

  • Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.

    Circulation

    Authors: Mohammed Rabiul Hosen, Philip Roger Goody, Andreas Zietzer, Xu Xiang, Sven Thomas Niepmann, Alexander Sedaghat, Vedat Tiyerili, Ramesh Chennupati, Joseph B Moore, Reinier A Boon, Shizuka Uchida, Jan-Malte Sinning, Sebastian Zimmer, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

  • Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.

    Nature metabolism

    Authors: Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K Holm, Christian M Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller

  • Immune response in COVID-19: what is next?

    Cell death and differentiation

    Authors: Qing Li, Ying Wang, Qiang Sun, Jasmin Knopf, Martin Herrmann, Liangyu Lin, Jingting Jiang, Changshun Shao, Peishan Li, Xiaozhou He, Fei Hua, Zubiao Niu, Chaobing Ma, Yichao Zhu, Giuseppe Ippolito, Mauro Piacentini, Jerome Estaquier, Sonia Melino, Felix Daniel Weiss, Emanuele Andreano, Eicke Latz, Joachim L Schultze, Rino Rappuoli, Alberto Mantovani, Tak Wah Mak, Gerry Melino, Yufang Shi