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featured publications

  • BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

    The Journal of experimental medicine

    Authors: Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L Greve, Markus W Löffler, Olaf-Oliver Wolz, Nadine A Schilling, Jasmin B Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N R Weber

  • Top publication

    Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.

    Cell

    Authors: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

  • Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.

    Cell reports

    Authors: Shanya Jiang, Nicole M Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A Mandell, Stephen D Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P Weick, Gary A Rosenberg, Eicke Latz, Michael T Heneka, Kiran Bhaskar

  • Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T Heneka

  • IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.

    Hypertension (Dallas, Tex. : 1979)

    Authors: Jordyn M Thomas, Yeong H Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M Ferens, Henry Diep, Shalini M Krishnan, Barbara K Kemp-Harper, Paul M O'Connor, Eicke Latz, Thiruma V Arumugam, Tomasz J Guzik, Michael J Hickey, Ashley Mansell, Christopher G Sobey, Antony Vinh, Grant R Drummond

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann

  • Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

    International immunology

    Authors: Kaiwen Liu, Ryota Sato, Takuma Shibata, Ryosuke Hiranuma, Tatjana Reuter, Ryutaro Fukui, Yun Zhang, Takeshi Ichinohe, Manabu Ozawa, Nobuaki Yoshida, Eicke Latz, Kensuke Miyake

  • The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis.

    Frontiers in molecular biosciences

    Authors: Sandra Torres, Maximilian J Brol, Fernando Magdaleno, Robert Schierwagen, Frank E Uschner, Sabine Klein, Cristina Ortiz, Olaf Tyc, Nadine Bachtler, James Stunden, Damien Bertheloot, Ana Kitanovic, Brian Sanchez, Jacob Schrum, William R Roush, Luigi Franchi, Kate Byth, Eicke Latz, Jonel Trebicka

  • Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.

    Journal of extracellular vesicles

    Authors: Christina F Budden, Linden J Gearing, Romina Kaiser, Lena Standke, Paul J Hertzog, Eicke Latz

  • Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.

    Clinical and translational allergy

    Authors: Hanna Bonnekoh, Carolina Vera, Angela Abad-Perez, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Niklas Amadeus Mahnke, Stefan Frischbutter, Eicke Latz, Marc Nazaré, Jens V Kries, Marcus Maurer, Jörg Scheffel, Karoline Krause