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Featured publications

  • Sensing soluble uric acid by Naip1-Nlrp3 platform.

    Cell death & disease

    Authors: Tarcio Teodoro Braga, Mariana Rodrigues Davanso, Davi Mendes, Tiago Antonio de Souza, Anderson Fernandes de Brito, Mario Costa Cruz, Meire Ioshie Hiyane, Dhemerson Souza de Lima, Vinicius Nunes, Juliana de Fátima Giarola, Denio Emanuel Pires Souto, Tomasz Próchnicki, Mario Lauterbach, Stellee Marcela Petris Biscaia, Rilton Alves de Freitas, Rui Curi, Alessandra Pontillo, Eicke Latz, Niels Olsen Saraiva Camara

  • Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.

    International journal of molecular sciences

    Authors: Shruthi Thada, Gabor L Horvath, Mario M Müller, Nickel Dittrich, Melanie L Conrad, Saubashya Sur, Abid Hussain, Karin Pelka, Suman Latha Gaddam, Eicke Latz, Hortense Slevogt, Ralf R Schumann, Sanne Burkert

  • Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid.

    Clinical science (London, England : 1979)

    Authors: Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi

  • Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

    Nature immunology

    Authors: Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo A B Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W M van der Meer, Musa Mhlanga, Simone J C F M Moorlag, Willem J M Mulder, Shruti Naik, Boris Novakovic, Luke O'Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea

  • The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.

    International immunology

    Authors: Ryota Sato, Tatjana Reuter, Ryosuke Hiranuma, Takuma Shibata, Ryutaro Fukui, Yuji Motoi, Yusuke Murakami, Hiroki Tsukamoto, Satoshi Yamazaki, Kaiwen Liu, Shin-Ichiroh Saitoh, Eicke Latz, Kensuke Miyake

  • Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.

    Cellular and molecular gastroenterology and hepatology

    Authors: Kai Markus Schneider, Carsten Elfers, Ahmed Ghallab, Carolin Victoria Schneider, Eric J C Galvez, Antje Mohs, Wenfang Gui, Lena Susanna Candels, Theresa Hildegard Wirtz, Sebastian Zuehlke, Michael Spiteller, Maiju Myllys, Alain Roulet, Amirouche Ouzerdine, Benjamin Lelouvier, Konrad Kilic, Lijun Liao, Anika Nier, Eicke Latz, Ina Bergheim, Christoph A Thaiss, Jan G Hengstler, Till Strowig, Christian Trautwein

  • Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.

    Journal of neurochemistry

    Authors: Frederic Brosseron, Kilian Kleemann, Carl-Christian Kolbe, Francesco Santarelli, Sergio Castro-Gomez, Pawel Tacik, Eicke Latz, Frank Jessen, Michael T Heneka

  • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.

    EBioMedicine

    Authors: Nathalie Niyonzima, Siril S Bakke, Ida Gregersen, Sverre Holm, Øystein Sandanger, Hilde L Orrem, Bjørnar Sporsheim, Liv Ryan, Xiang Yi Kong, Tuva Børresdatter Dahl, Mona Skjelland, Kirsten Krohg Sørensen, Anne Mari Rokstad, Arne Yndestad, Eicke Latz, Lars Gullestad, Geir Ø Andersen, Jan Kristian Damås, Pål Aukrust, Tom E Mollnes, Bente Halvorsen, Terje Espevik

  • 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.

    Autophagy

    Authors: Mario A Lauterbach, Victor Saavedra, Matthew S J Mangan, Anke Penno, Christoph Thiele, Eicke Latz, Lars Kuerschner

  • Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Mice.

    Metabolites

    Authors: Mario A Lauterbach, Eicke Latz, Anette Christ