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Publications

featured publications

  • Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.

    Cell reports

    Authors: Shanya Jiang, Nicole M Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A Mandell, Stephen D Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P Weick, Gary A Rosenberg, Eicke Latz, Michael T Heneka, Kiran Bhaskar

  • Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T Heneka

  • IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.

    Hypertension (Dallas, Tex. : 1979)

    Authors: Jordyn M Thomas, Yeong H Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M Ferens, Henry Diep, Shalini M Krishnan, Barbara K Kemp-Harper, Paul M O'Connor, Eicke Latz, Thiruma V Arumugam, Tomasz J Guzik, Michael J Hickey, Ashley Mansell, Christopher G Sobey, Antony Vinh, Grant R Drummond

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann

  • Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

    International immunology

    Authors: Kaiwen Liu, Ryota Sato, Takuma Shibata, Ryosuke Hiranuma, Tatjana Reuter, Ryutaro Fukui, Yun Zhang, Takeshi Ichinohe, Manabu Ozawa, Nobuaki Yoshida, Eicke Latz, Kensuke Miyake

  • The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis.

    Frontiers in molecular biosciences

    Authors: Sandra Torres, Maximilian J Brol, Fernando Magdaleno, Robert Schierwagen, Frank E Uschner, Sabine Klein, Cristina Ortiz, Olaf Tyc, Nadine Bachtler, James Stunden, Damien Bertheloot, Ana Kitanovic, Brian Sanchez, Jacob Schrum, William R Roush, Luigi Franchi, Kate Byth, Eicke Latz, Jonel Trebicka

  • Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.

    Journal of extracellular vesicles

    Authors: Christina F Budden, Linden J Gearing, Romina Kaiser, Lena Standke, Paul J Hertzog, Eicke Latz

  • Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.

    Clinical and translational allergy

    Authors: Hanna Bonnekoh, Carolina Vera, Angela Abad-Perez, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Niklas Amadeus Mahnke, Stefan Frischbutter, Eicke Latz, Marc Nazaré, Jens V Kries, Marcus Maurer, Jörg Scheffel, Karoline Krause

  • Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.

    The FEBS journal

    Authors: Nathaniel L Hepowit, Carl-Christian Kolbe, Sarah R Zelle, Eicke Latz, Jason A MacGurn

  • Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury.

    American journal of respiratory and critical care medicine

    Authors: Konrad Peukert, Mario Fox, Susanne Schulz, Caroline Feuerborn, Stilla Frede, Christian Putensen, Hermann Wrigge, Beate Mareike Kümmerer, Sascha David, Benjamin Seeliger, Tobias Welte, Eicke Latz, Dennis Klinman, Christoph Wilhelm, Folkert Steinhagen, Christian Bode